Roland S. Croner

TL;DR: Hepatic platelet-endothelial interaction is an early event during endotoxemia, which underlines the probable involvement of platelets in leukocyte recruitment and makes the existence of autoregulatory liver mechanisms likely.

TL;DR: CCL2 upregulation in metastatic UICC stage IV colon carcinomas is described and it is demonstrated that tumor cell-derived CCL2 activates the CCR2(+) endothelium to increase vascular permeability in vivo.

TL;DR: The clinicopathological spectrum of gastrointestinal manifestations of NF-1 including putative proliferative precursor lesions are summarized and discussed with emphasis on the differential diagnostic aspects of these disorders and their molecular pathogenesis.

TL;DR: Combined low PD-L1 expression on tumour and inflammatory cells is an independent negative prognostic marker for OS in RCT of rectal adenocarcinoma patients, which should prompt clinical trials combining radiotherapy and PD-1/PD-L 1 pathway blockade.

TL;DR: The high percentage of R0 resections achieved through multivisceral resection justifies this procedure for locally advanced colon carcinomas and highlights the importance of experienced, well-trained surgeons to decrease the incidence of locoregional recurrence.