R
Roland Tubiana
Researcher at University of Paris
Publications - 163
Citations - 6343
Roland Tubiana is an academic researcher from University of Paris. The author has contributed to research in topics: Viral load & Medicine. The author has an hindex of 40, co-authored 149 publications receiving 5807 citations. Previous affiliations of Roland Tubiana include University of Amsterdam & Paris-Sorbonne University.
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Journal ArticleDOI
Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease
TL;DR: HAART can induce sustained recovery of CD4 T-cell reactivity against opportunistic pathogens in severely immunosuppressed patients, and this recovery depends not on baseline values but on the amplitude and duration of viral-load reduction and the increase of memoryCD4 T cells.
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Discordance between cerebral spinal fluid and plasma HIV replication in patients with neurological symptoms who are receiving suppressive antiretroviral therapy.
Ana Canestri,Franæois-Xavier Lescure,Stéphane Jauréguiberry,Antoine Moulignier,Corinne Amiel,Anne-Geneviève Marcelin,Anne-Geneviève Marcelin,Gilles Peytavin,Roland Tubiana,Gilles Pialoux,Christine Katlama,Christine Katlama +11 more
TL;DR: Despite successful suppression of plasma viremia with antiretroviral therapy, HIV may replicate in CSF, with development of CSF HIV resistance resulting in acute or subacute neurological manifestations.
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Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort.
Josiane Warszawski,Roland Tubiana,Jérôme Le Chenadec,Stéphane Blanche,Jean-Paul Teglas,Catherine Dollfus,Albert Faye,Marianne Burgard,Christine Rouzioux,Laurent Mandelbrot,Anrs French Perinatal Cohort +10 more
TL;DR: Low maternal plasma viral load is the key factor for preventing mother-to-child HIV-1 transmission from mothers receiving antenatal antiretroviral therapy, and benefits in terms of MTCT reduction may be expected from early antireTroviral prophylaxis.
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No Perinatal HIV-1 Transmission From Women With Effective Antiretroviral Therapy Starting Before Conception
Laurent Mandelbrot,Roland Tubiana,Jérôme Le Chenadec,Catherine Dollfus,Albert Faye,Emmanuelle Pannier,Sophie Matheron,Marie-Aude Khuong,Valérie Garrait,Véronique Reliquet,Alain Devidas,Alain Berrebi,Christine Allisy,Christophe Elleau,Cédric Arvieux,Christine Rouzioux,Josiane Warszawski,Stéphane Blanche +17 more
TL;DR: Perinatal HIV-1 transmission is virtually zero in mothers who start ART before conception and maintain suppression of plasma VL.
Journal ArticleDOI
HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment
Avidan U. Neumann,Roland Tubiana,Vincent Calvez,Catherine Robert,T.S. Li,Henri Agut,Brigitte Autran,Christine Katlama +7 more
TL;DR: The reintroduction of efficient ART therapy after a 1 month interruption shows viral kinetics similar to that of naive patients, and is not associated with the development of resistance.