R
Rolf Felix
Researcher at University of Bern
Publications - 61
Citations - 5333
Rolf Felix is an academic researcher from University of Bern. The author has contributed to research in topics: Bone resorption & Osteoclast. The author has an hindex of 34, co-authored 61 publications receiving 5192 citations.
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Journal ArticleDOI
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Agamemnon E. Grigoriadis,Zhao-Qi Wang,Marco G. Cecchini,Willy Hofstetter,Rolf Felix,Herbert Fleisch,Erwin F. Wagner +6 more
TL;DR: Results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases.
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Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse
Marco G. Cecchini,M.G. Dominguez,S. Mocci,Antoinette Wetterwald,Rolf Felix,Herbert Fleisch,Orin Chisholm,Willy Hofstetter,J.W. Pollard,E.R. Stanley +9 more
TL;DR: The studies suggest that circulating CSF-1 exclusively regulates both the F4/80+ cells in the liver, spleen and kidney and the MOMA-1+ metallophilic macrophages in the spleen.
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Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse
TL;DR: The treatment restores the bone marrow cavity virtually absent in the op/op animal and induces the appearance of resorbing osteoclasts and of resident bone marrow macrophages, proving that the deficiency of M-CSF is the cause of the op-op bone disorder and that this cytokine is directly or indirectly necessary for physiological osteoclastogenesis, the resulting bone resorption and for the establishment of bone marrow hemopoiesis.
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Structure-activity relationships of various bisphosphonates
TL;DR: Taking into account all factors, 1-hydroxypentylidene-1,1-bisphosphonate and AHPrBP seem to be the most active compounds to inhibit bone resorption.
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Rapid publication: Impairment of macrophage colony‐stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op Mouse
TL;DR: Results suggest that both M‐CSF and resident macrophages play a role in the mechanism of bone resorption, and the op/op mouse appears to be a valuable model to further investigate such a hypothesis.