A
Agamemnon E. Grigoriadis
Researcher at Research Institute of Molecular Pathology
Publications - 19
Citations - 3183
Agamemnon E. Grigoriadis is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Bone remodeling & Biology. The author has an hindex of 11, co-authored 14 publications receiving 3086 citations. Previous affiliations of Agamemnon E. Grigoriadis include Guy's Hospital & Karlsruhe Institute of Technology.
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Journal ArticleDOI
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Agamemnon E. Grigoriadis,Zhao-Qi Wang,Marco G. Cecchini,Willy Hofstetter,Rolf Felix,Herbert Fleisch,Erwin F. Wagner +6 more
TL;DR: Results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases.
Journal ArticleDOI
Bone and haematopoietic defects in mice lacking c-fos
Zhao-Qi Wang,Catherine E. Ovitt,Agamemnon E. Grigoriadis,Uta Möhle-Steinlein,U. Rüther,Erwin F. Wagner +5 more
TL;DR: It is reported that heterozygous fos +/− mice appear normal, although females exhibit a distorted transmission frequency, which defines the c-Fos protein as an essential molecule for the development of specific cellular compartments.
Journal ArticleDOI
Osteoblasts are target cells for transformation in c-fos transgenic mice.
TL;DR: It is suggested that high levels of Fos perturb the normal growth control of osteoblastic cells and exert specific effects on the expression of the osteoblast phenotype.
Journal ArticleDOI
A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.
TL;DR: It is demonstrated that chondrogenic cells and earlier progenitors are specially transformed by Fos/Jun and therefore represent a novel mesenchymal target cell for c‐fos overexpression andTherefore, the levels of c‐Fos and c‐Jun appeared to be coordinately regulated in the cell lines as well as in chimeric tissues.
Journal Article
Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes.
Sabine Gack,Rüdiger Vallon,Jörg Schmidt,Agamemnon E. Grigoriadis,Jan Tuckermann,Johannes Schenkel,Hans Weiher,Erwin F. Wagner,Peter Angel +8 more
TL;DR: The tissue-specific expression of MMP-1 and the exclusive ability of interstitial collagenase to digest native collagen of types I, II, III, and X, the major components of bone, cartilage, and tendon, strongly suggests an important and specific function of this enzyme in bone development and remodeling.