R
Romain Boidot
Researcher at French Institute of Health and Medical Research
Publications - 120
Citations - 4354
Romain Boidot is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 28, co-authored 94 publications receiving 3000 citations. Previous affiliations of Romain Boidot include Université catholique de Louvain & University of Burgundy.
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Journal ArticleDOI
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
TL;DR: The findings establish a signaling role for lactate in endothelial cells and they identify the lactate/NF-κB/IL-8 pathway as an important link between tumor metabolism and angiogenesis.
Journal ArticleDOI
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.
Mélanie Bruchard,Cédric Rébé,Valentin Derangère,Dieudonnée Togbe,Bernhard Ryffel,Romain Boidot,Etienne Humblin,Arlette Hamman,Fanny Chalmin,Hélène Berger,Angélique Chevriaux,Emeric Limagne,Lionel Apetoh,Frédérique Végran,François Ghiringhelli +14 more
TL;DR: The results demonstrate the ability of NLRP3 to act as a key transcription factor in TH2 differentiation and specifically supported a T helper type 2 (TH2) transcriptional program in a cell-intrinsic manner.
Journal ArticleDOI
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells
Frédérique Végran,Hélène Berger,Romain Boidot,Grégoire Mignot,Mélanie Bruchard,Magalie Dosset,Fanny Chalmin,Cédric Rébé,Valentin Derangère,Bernhard Ryffel,Masashi Kato,Armelle Prévost-Blondel,François Ghiringhelli,Lionel Apetoh +13 more
TL;DR: It is found that the transcription factor IRF1 enhanced the effector function of TH9 cells and dictated their anticancer properties.
Journal ArticleDOI
Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen
Emeric Limagne,Romain Euvrard,Marion Thibaudin,Cédric Rébé,Valentin Derangère,Angélique Chevriaux,Romain Boidot,Frédérique Végran,Nathalie Bonnefoy,Julie Vincent,Leila Bengrine-Lefevre,Sylvain Ladoire,Dominique Delmas,Lionel Apetoh,François Ghiringhelli +14 more
TL;DR: This work underscores the critical prognostic impact of early modifications in Th17 and gMDSC frequency in mCRC and provides a clinical rationale to combine FOLFOX-bevacizumab chemotherapy with inhibitors of ATP ectonucleotidases and/or anti-PD-1/PD-L1 antibodies to more effectively treat this disease.
Journal ArticleDOI
Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.
Romain Boidot,Frédérique Végran,Aline Meulle,Aude Le Breton,Chantal Dessy,Pierre Sonveaux,Sarab Lizard-Nacol,Olivier Feron +7 more
TL;DR: MCT1 is identified as a target for p53 repression and it is suggested that MCT1 elevation in p53-deficient tumors allows them to adapt to metabolic needs by facilitating lactate export or import depending on the glucose availability.