R
Roman Reinartz
Researcher at University of Bonn
Publications - 9
Citations - 635
Roman Reinartz is an academic researcher from University of Bonn. The author has contributed to research in topics: Temozolomide & Stem cell. The author has an hindex of 9, co-authored 9 publications receiving 545 citations.
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Journal ArticleDOI
Anticancer Effects of Niclosamide in Human Glioblastoma
Anja Wieland,Daniel Trageser,Sabine Gogolok,Roman Reinartz,Heike Höfer,Mihaela Keller,Anke Leinhaas,Ramona Schelle,Sabine Normann,Lil Klaas,Andreas Waha,Philipp Koch,Rolf Fimmers,Torsten Pietsch,Anthony T. Yachnis,David W. Pincus,Dennis A. Steindler,Oliver Brüstle,Matthias Simon,Martin Glas,Björn Scheffler +20 more
TL;DR: Together, the data advocate the use of pGBMs for exploration of compound libraries to reveal unexpected leads, for example, niclosamide that might be suited for further development toward personalized clinical application.
Journal ArticleDOI
Susceptibility variants for male-pattern baldness on chromosome 20p11
Axel M. Hillmer,Felix F. Brockschmidt,Sandra Hanneken,Sibylle Eigelshoven,Michael Steffens,Antonia Flaquer,Stefan Herms,Tim Becker,Anne-Katrin Kortüm,Dale R. Nyholt,Zhen Zhen Zhao,Grant W. Montgomery,Nicholas G. Martin,Thomas W. Mühleisen,Margrieta A. Alblas,Susanne Moebus,Karl-Heinz Jöckel,Martina Bröcker-Preuss,Raimund Erbel,Roman Reinartz,Regina C. Betz,Sven Cichon,Peter Propping,Max P. Baur,Thomas F. Wienker,Roland Kruse,Markus M. Nöthen +26 more
TL;DR: This article carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls and investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15).
Journal ArticleDOI
Residual tumor cells are unique cellular targets in glioblastoma
Martin Glas,Barbara H. Rath,Matthias Simon,Roman Reinartz,Anja Schramme,Daniel Trageser,Ramona Eisenreich,Anke Leinhaas,Mihaela Keller,Hans-Ulrich Schildhaus,Stephan Garbe,Barbara Steinfarz,Torsten Pietsch,Dennis A. Steindler,Johannes Schramm,Ulrich Herrlinger,Oliver Brüstle,Björn Scheffler +17 more
TL;DR: In vitro analysis of proliferation, invasion, stem cell qualities, GBM‐typical antigens, genotypes, and in vitro drug and irradiation challenge studies revealed residual tumor cells as unique entities.
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Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma
Martin Glas,Christoph Coch,Daniel Trageser,Juliane Daßler,Matthias Simon,Philipp Koch,Jerome Mertens,Tamara Quandel,Raphaela Gorris,Roman Reinartz,Anja Wieland,Marec von Lehe,Annette Pusch,Kristin Roy,Martin Schlee,Harald Neumann,Rolf Fimmers,Ulrich Herrlinger,Oliver Brüstle,Gunther Hartmann,Robert Besch,Björn Scheffler +21 more
TL;DR: Activation of the innate immune system by stimulation of innate immune receptors involved in antiviral and antitumor responses can similarly target different malignant populations of glioma cells.
Journal ArticleDOI
Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26
Axel M. Hillmer,Antonia Flaquer,Sandra Hanneken,Sibylle Eigelshoven,Anne-Katrin Kortüm,Felix F. Brockschmidt,Astrid Golla,Christine Metzen,Holger Thiele,Susanne Kolberg,Roman Reinartz,Regina C. Betz,Thomas Ruzicka,Thomas Ruzicka,Hans Christian Hennies,Roland Kruse,Markus M. Nöthen +16 more
TL;DR: A genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent finds the locus with strongest evidence for linkage was mapped to 3q26.