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Ronald A. Lubet

Researcher at National Institutes of Health

Publications -  328
Citations -  16142

Ronald A. Lubet is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 63, co-authored 323 publications receiving 15589 citations. Previous affiliations of Ronald A. Lubet include Medical College of Wisconsin.

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Journal ArticleDOI

Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.

Ronald A. Lubet, +6 more
- 01 Apr 1985 - 
TL;DR: The O-dealkylation of pentoxyresorufin by rat liver microsomes was examined and it was observed that this activity, in microsome for Aroclor-pretreated rats, was dependent on O2 and was inhibited by metyrapone and SKF 525-A, indicative of cytochrome P-450 mediation in the reaction.
Journal Article

Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of Colon Cancer

Toshihiko Kawamori, +6 more
- 01 Feb 1999 - 
TL;DR: Administration of curcumin to the rats during the initiation and postinitiation stages and throughout the promotion/progression stage increased apoptosis in the colon tumors as compared to colon tumors in the groups receiving AOM and the control diet.
Journal Article

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

Russell F. Jacoby, +4 more
- 15 Sep 2000 - 
TL;DR: These results provide the first evidence that selective inhibitors of COX-2 are safe and effective for the prevention and regression of adenomas in a mouse model ofAdenomatous polyposis and strongly support ongoing clinical trials in humans with the same syndrome.
Journal Article

Chemoprevention of Colon Cancer by Specific Cyclooxygenase-2 Inhibitor, Celecoxib, Administered during Different Stages of Carcinogenesis

Bandaru S. Reddy, +7 more
- 15 Jan 2000 - 
TL;DR: This study provides the first evidence that celecoxib is also very effective when it is given during the promotion/progression stage of colon carcinogenesis, indicating that the chemopreventive efficacy is achieved during the later stages of colon tumor development.
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Progress in Cancer chemoprevention : Development of diet-derived chemopreventive agents

Gary J. Kelloff, +12 more
- 01 Feb 2000 - 
TL;DR: Because of their safety and the fact that they are not perceived as "medicine," food-derived products are highly interesting for development as chemopreventive agents that may find widespread, long-term use in populations at normal risk.