Showing papers by "Ronald Breslow published in 2012"
TL;DR: Single-molecule conductance measurements and transport calculations based on density functional theory show that the conductance of a double-backbone molecular junction can be more than twice that of a single- backbone junction, providing clear evidence for constructive interference.
Abstract: Kirchhoff's conductance superposition law is investigated in single-molecule circuits. A single-molecule junction with two backbones in a parallel configuration can exhibit more than twice the conductance of a single-molecule junction with one backbone, a demonstration of constructive quantum interference.
309 citations
TL;DR: A scheme is described in which these cleavages could be made sequence selective with various RNAs, particularly with important targets, such as viral RNAs.
Abstract: Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each nitrogen of the polymers. They were characterized by gel permeation chromatography and had very low polydispersities. When they were partially protonated they bound to the poly(U) and catalyzed its cleavage by a process analogous to that used by the enzyme ribonuclease A. The kinetics of the cleavage were followed by an assay we had previously described using phosphodiesterase I from Crotalus venom after the cleavage processes. Cleavage of poly(U) with Zn2+ was also examined, with and without the polymers. A scheme is described in which these cleavages could be made sequence selective with various RNAs, particularly with important targets, such as viral RNAs.
24 citations
Patent•
03 Oct 2012
TL;DR: In this paper, the HDAC6 selective inhibitors are identified on the basis of accumulation of acetylated tubulin without accumulation of histones, and the compounds are used to inhibit the activity of histone deacetylase, including for treatment.
Abstract: The compounds of the present invention are HDAC6 selective inhibitors which are identified on the basis of accumulation of acetylated tubulin without accumulation of acetylated histones. Histone deacetylase or "HDAC" refers to enzymes capable of cleaving an acetyl group (-C(=0)CH3) from proteins, including histone and microtubulins. Compositions comprising the molecules and methods for their use to inhibit the activity of histone deacetylase, including for treatment, are also disclosed.
20 citations