R
Rachid Skouta
Researcher at University of Massachusetts Amherst
Publications - 60
Citations - 16051
Rachid Skouta is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Catalysis & Programmed cell death. The author has an hindex of 25, co-authored 57 publications receiving 8907 citations. Previous affiliations of Rachid Skouta include McGill University & Center for Functional Nanomaterials.
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Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
Journal ArticleDOI
Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang,Rohitha SriRamaratnam,Matthew Welsch,Kenichi Shimada,Rachid Skouta,Vasanthi S. Viswanathan,Vasanthi S. Viswanathan,Jaime H. Cheah,Paul A. Clemons,Alykhan F. Shamji,Clary B. Clish,Lewis M. Brown,Albert W. Girotti,Virginia W. Cornish,Stuart L. Schreiber,Brent R. Stockwell +15 more
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
Journal ArticleDOI
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
Scott J. Dixon,Darpan N Patel,Matthew Welsch,Rachid Skouta,Eric D Lee,Miki Hayano,Ajit G. Thomas,Caroline E Gleason,Nicholas P. Tatonetti,Barbara S. Slusher,Brent R. Stockwell +10 more
TL;DR: Dixon, Patel, et al. as mentioned in this paper found that erastin is a very effective inhibitor of system xc− function and that it is over 1000 times more potent than the previously known best inhibitor, sulfasalazine.
Journal ArticleDOI
Synchronized renal tubular cell death involves ferroptosis
Andreas Linkermann,Rachid Skouta,Nina Himmerkus,Shrikant R. Mulay,Christin Dewitz,Federica De Zen,Ágnes Prókai,Gabriele Zuchtriegel,Fritz Krombach,Patrick Simon Welz,Ricardo Weinlich,Tom Vanden Berghe,Tom Vanden Berghe,Peter Vandenabeele,Peter Vandenabeele,Manolis Pasparakis,Markus Bleich,Joel M. Weinberg,Christoph A. Reichel,Jan Hinrich Bräsen,Ulrich Kunzendorf,Hans-Joachim Anders,Brent R. Stockwell,Douglas R. Green,Stefan Krautwald +24 more
TL;DR: It is demonstrated that renal tubules do not undergo sensitization to necroptosis upon genetic ablation of either FADD or caspase-8 and that the RIPK1 inhibitor necrostatin-1 (Nec-1) does not protect freshly isolated tubules from hypoxic injury, and ferroptosis mediates postischemic and toxic renal necrosis.
Journal ArticleDOI
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.
Rachid Skouta,Scott J. Dixon,Jianlin Wang,Denise E. Dunn,Marina Orman,Kenichi Shimada,Paul A. Rosenberg,Donald C. Lo,Joel M. Weinberg,Andreas Linkermann,Brent R. Stockwell +10 more
TL;DR: A mechanistic model to explain the activity of Fer-1 was developed, which guided the development of ferrostatins with improved properties, and that lipid peroxidation mediates diverse disease phenotypes are suggested.