R
Ronald E. Baynes
Researcher at North Carolina State University
Publications - 180
Citations - 2926
Ronald E. Baynes is an academic researcher from North Carolina State University. The author has contributed to research in topics: Absorption (skin) & Flunixin. The author has an hindex of 26, co-authored 172 publications receiving 2557 citations. Previous affiliations of Ronald E. Baynes include North Carolina State University College of Veterinary Medicine.
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Journal ArticleDOI
Health concerns and management of select veterinary drug residues.
Ronald E. Baynes,Keith D. DeDonder,L. W. Kissell,Danielle A. Mzyk,Tara Marmulak,Geof W. Smith,Lisa A. Tell,R. Gehring,Jennifer Davis,Jim E. Riviere +9 more
TL;DR: The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals and how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments.
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Pharmacokinetics of melamine in pigs following intravenous administration.
TL;DR: The pharmacokinetic parameters for melamine obtained in pigs are comparable to the only mammalian study in rats and suggests that melamine is readily cleared by the kidney and there is unlikely to be significant tissue binding.
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A physiologically based pharmacokinetic model of organophosphate dermal absorption.
D. van der Merwe,James D. Brooks,R. Gehring,Ronald E. Baynes,Nancy A. Monteiro-Riviere,Jim E. Riviere +5 more
TL;DR: The similarity between the overall shapes of the experimental and model-predicted flux/time curves and the successful simulation of altered system conditions for this series of small, lipophilic compounds indicated that the absorption processes were successfully simulated important aspects of dermal absorption in flow-through cells.
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Use of Probabilistic Modeling within a Physiologically Based Pharmacokinetic Model To Predict Sulfamethazine Residue Withdrawal Times in Edible Tissues in Swine
TL;DR: Probabilistic modeling techniques incorporated into a physiologically based pharmacokinetic (PBPK) model were used to predict the amounts of sulfamethazine residues in edible tissues in swine to calculate the withdrawal time by using the tolerance limit algorithm designed by FDA.
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Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model
TL;DR: A physiologically based pharmacokinetic model for melamine was developed for rats and extrapolated to pigs, providing evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species.