Ronald G. Kase

TL;DR: The frequency of the clinical and radiological anomalies in Nevoid basal cell carcinoma syndrome in a large population of US patients is delineated and guidelines for diagnosis and management are discussed.

TL;DR: Gorlin syndrome is an autosomal dominant disorder that predisposes to basal cell carcinomas of the skin, ovarian fibromas, and medulloblastomas and all informative kindreds showed tight linkage between the Gorlin syndrome gene and a genetic marker in this region.

TL;DR: Prophylactic oophorectomy was performed in 28 female members of 16 families at high risk of ovarian carcinoma, finding that in cancer-prone families the susceptible tissue is not limited to the ovary, but includes other derivatives of the coelomic epithelium from which primary peritoneal neoplasms may arise.

TL;DR: A high level of interest in genetic testing for BRCA1 among members of inherited breast-ovarian cancer families participating in a genetic linkage study is found and utilization may fall below levels of interest reported in this and other preliminary surveys.

TL;DR: In this article, the authors identify factors affecting genetic testing decisions in a cohort of hereditary breast and ovarian cancer (HBOC) families presented with the choice to undergo testing and found that those who chose to undergo genetic testing were more likely to be older (> or =40 years, to have lower levels of optimism, and to report higher levels of cohesiveness in their families.