M
Margaret A. Tucker
Researcher at National Institutes of Health
Publications - 338
Citations - 40994
Margaret A. Tucker is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Cancer. The author has an hindex of 93, co-authored 328 publications receiving 38600 citations. Previous affiliations of Margaret A. Tucker include Sheba Medical Center.
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Journal ArticleDOI
The Risk of Cancer Associated with Specific Mutations of BRCA1 and BRCA2 among Ashkenazi Jews
Jeffery P. Struewing,Patricia Hartge,Sholom Wacholder,Sonya M. Baker,Martha Berlin,Mary McAdams,Michelle M. Timmerman,Lawrence C. Brody,Margaret A. Tucker +8 more
TL;DR: The risks of breast cancer may be overestimated, but they fall well below previous estimates based on subjects from high-risk families.
Journal ArticleDOI
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
David J. Hunter,David J. Hunter,Peter Kraft,Kevin B. Jacobs,David G. Cox,Meredith Yeager,Meredith Yeager,Susan E. Hankinson,Sholom Wacholder,Zhaoming Wang,Zhaoming Wang,Robert W Welch,Robert W Welch,Amy Hutchinson,Amy Hutchinson,Junwen Wang,Junwen Wang,Kai Yu,Nilanjan Chatterjee,Nick Orr,Walter C. Willett,Graham A. Colditz,Regina G. Ziegler,Christine D. Berg,Saundra S. Buys,Catherine A. McCarty,Heather Spencer Feigelson,Eugenia E. Calle,Michael J. Thun,Richard B. Hayes,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,Gilles Thomas,Stephen J. Chanock +35 more
TL;DR: Four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer were identified and confirmed in 1,776 affected individuals and 2,072 controls from three additional studies.
Journal ArticleDOI
Replicating genotype–phenotype associations
Stephen J. Chanock,Teri A. Manolio,Michael Boehnke,Eric Boerwinkle,David J. Hunter,Gilles Thomas,Joel N. Hirschhorn,Gonçalo R. Abecasis,David Altshuler,Joan E. Bailey-Wilson,Lisa D. Brooks,Lon R. Cardon,Mark J. Daly,Peter Donnelly,Joseph F. Fraumeni,Nelson B. Freimer,Daniela S. Gerhard,Chris Gunter,Alan E. Guttmacher,Mark S. Guyer,Emily L. Harris,Josephine Hoh,Robert N. Hoover,C. Augustine Kong,Kathleen R. Merikangas,Cynthia C. Morton,Lyle J. Palmer,Elizabeth G. Phimister,John P. Rice,Jerry Roberts,Charles N. Rotimi,Margaret A. Tucker,Kyle Vogan,Sholom Wacholder,Ellen M. Wijsman,Deborah M. Winn,Francis S. Collins +36 more
TL;DR: What constitutes replication of a genotype–phenotype association, and how best can it be achieved, is investigated.
Journal Article
A cancer family syndrome in twenty-four kindreds.
Frederick P. Li,Joseph F. Fraumeni,John J. Mulvihill,William A. Blattner,Margaret G. Dreyfus,Margaret A. Tucker,Robert W. Miller +6 more
TL;DR: The diversity of tumor types in this syndrome suggests pathogenetic mechanisms which differ from hereditary cancers arising in single organs or tissues and laboratory markers are needed to identify high-risk individuals and families and to provide insights into susceptibility mechanisms that may be shared by a wide variety of cancers.
Journal ArticleDOI
Germline p16 mutations in familial melanoma.
Christopher J. Hussussian,Jeffery P. Struewing,Alisa M. Goldstein,Paul A. T. Higgins,Delphine S. Ally,Michelle D. Sheahan,Wallace H. Clark,Margaret A. Tucker,Nicholas C. Dracopoli +8 more
TL;DR: Nine melanoma-specific mutations were detected in 9p21-linked, but not in 1p36- linked, families, thereby confirming previous reports of genetic heterogeneity and will confirm those causally related to the development of familial melanoma.