R
Ronald Simon
Researcher at University of Münster
Publications - 19
Citations - 1719
Ronald Simon is an academic researcher from University of Münster. The author has contributed to research in topics: Comparative genomic hybridization & Ductal carcinoma. The author has an hindex of 13, co-authored 19 publications receiving 1695 citations.
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Journal ArticleDOI
Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.
Horst Buerger,Friedrich Otterbach,Ronald Simon,Christopher Poremba,Raihanatou Diallo,Thomas Decker,Lutz Riethdorf,C. Brinkschmidt,Barbara Dockhorn-Dworniczak,Werner Boecker +9 more
TL;DR: Analysis of paraffin‐embedded specimens of DCIS and six associated invasive carcinomas revealed a genetic pattern almost identical to the one seen in the DCIS counterpart, characterize DCIS as a genetically far‐advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer.
Journal ArticleDOI
Different genetic pathways in the evolution of invasive breast cancer are associated with distinct morphological subtypes.
Horst Buerger,Friedrich Otterbach,Ronald Simon,K L Schäfer,Christopher Poremba,Raihanatou Diallo,C. Brinkschmidt,Barbara Dockhorn-Dworniczak,Werner Boecker +8 more
TL;DR: Data demonstrate the close genetic similarity of well‐, intermediately, and poorly differentiated DCIS and distinct morphological types of invasive breast carcinoma, providing further evidence that DCIS is a direct precursor lesion ofvasive breast cancer and that various evolutionary genetic pathways exist.
Journal Article
Length and Loss of Heterozygosity of an Intron 1 Polymorphic Sequence of egfr Is Related to Cytogenetic Alterations and Epithelial Growth Factor Receptor Expression
Horst Buerger,Frank Gebhardt,Hartmut Schmidt,Alf Beckmann,Kirsten Hutmacher,Ronald Simon,Ralph J. Lellé,Werner Boecker,Burkhard Brandt +8 more
TL;DR: It is concluded that the CA repeat status in intron 1 of the egfr gene also modulates the intratumoral EGFR content in vivo and is associated with genetically advanced tumors.
Journal ArticleDOI
Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution.
Horst Buerger,Ellen C.M. Mommers,Ruth Littmann,Ronald Simon,Raihanatou Diallo,Christopher Poremba,Barbara Dockhorn-Dworniczak,Paul J. van Diest,Werner Boecker +8 more
TL;DR: The findings of this study demonstrate that ductal invasive G2 carcinomas have to be interpreted as the morphological end stage resulting from two different cytogenetics and morphological pathways; the loss of 16q material is the cytogenetic key event in the evolution of a subgroup of this entity.
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Chromosomal aberrations associated with invasion in papillary superficial bladder cancer.
TL;DR: These data show characteristic chromosomal aberrations associated with invasion in superficial bladder cancer.