B
Barbara Dockhorn-Dworniczak
Researcher at University of Münster
Publications - 111
Citations - 5748
Barbara Dockhorn-Dworniczak is an academic researcher from University of Münster. The author has contributed to research in topics: Comparative genomic hybridization & Sarcoma. The author has an hindex of 41, co-authored 111 publications receiving 5607 citations. Previous affiliations of Barbara Dockhorn-Dworniczak include University of Pennsylvania & University of Düsseldorf.
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Journal ArticleDOI
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Simone Fulda,Martin U Küfer,Eric P. Meyer,Frans van Valen,Barbara Dockhorn-Dworniczak,Klaus-Michael Debatin +5 more
TL;DR: Findings indicate that re-expression of caspase-8, e.g. by demethylation or casp enzyme-8 gene transfer, might be an effective strategy to restore sensitivity for chemotherapy- or death receptor-induced apoptosis in various tumors in vivo.
Journal ArticleDOI
Localized Ewing Tumor of Bone: Final Results of the Cooperative Ewing’s Sarcoma Study CESS 86
M. Paulussen,S. Ahrens,Juergen Dunst,W. Winkelmann,G. U. Exner,Rainer Kotz,Gabriele Amann,Barbara Dockhorn-Dworniczak,D. Harms,St. Müller-Weihrich,Karl Welte,B. Kornhuber,Gritta Janka-Schaub,Ulrich Göbel,Jörn Treuner,P. A. Voûte,Andreas Zoubek,Helmut Gadner,Heribert Jürgens +18 more
TL;DR: Fifty-two percent of CESS 86 patients survived after risk-adapted therapy, and high-risk patients seem to have benefited from intensified treatment that incorporated ifosfamide, in multivariate analyses.
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Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.
Horst Buerger,Friedrich Otterbach,Ronald Simon,Christopher Poremba,Raihanatou Diallo,Thomas Decker,Lutz Riethdorf,C. Brinkschmidt,Barbara Dockhorn-Dworniczak,Werner Boecker +9 more
TL;DR: Analysis of paraffin‐embedded specimens of DCIS and six associated invasive carcinomas revealed a genetic pattern almost identical to the one seen in the DCIS counterpart, characterize DCIS as a genetically far‐advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer.
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Primary metastatic (stage IV) Ewing tumor: Survival analysis of 171 patients from the EICESS studies
M. Paulussen,S. Ahrens,S Burdach,Alan W. Craft,Barbara Dockhorn-Dworniczak,Juergen Dunst,B. Fröhlich,W. Winkelmann,Andreas Zoubek,Herbert Jürgens +9 more
TL;DR: Whole lung irradiation and megatherapy improve outcome in subgroups of patients with disseminated Ewing tumors is 0.27, and whole lung irradiated patients with combined pulmonary/skeletal metastases with combined lung plus bone/BM metastases improve outcome.
Journal ArticleDOI
Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor Patients
Andreas Zoubek,Barbara Dockhorn-Dworniczak,Olivier Delattre,Holger Christiansen,Felix Niggli,I Gatterer-Menz,T L Smith,Heribert Jürgens,Helmut Gadner,Heinrich Kovar +9 more
TL;DR: Results suggest a possible advantage in PFS for patients with localized disease and fusion type I transcripts, although this will require prospective validation with a larger number of patients and longer follow-up periods.