E
Ellis Jaffray
Researcher at University of Dundee
Publications - 57
Citations - 6013
Ellis Jaffray is an academic researcher from University of Dundee. The author has contributed to research in topics: SUMO protein & Ubiquitin. The author has an hindex of 37, co-authored 55 publications receiving 5587 citations. Previous affiliations of Ellis Jaffray include University of St Andrews.
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Journal ArticleDOI
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9
Michael H. Tatham,Ellis Jaffray,Owen A. Vaughan,Joana M. P. Desterro,Catherine H. Botting,James H. Naismith,Ronald T. Hay +6 more
TL;DR: The ability to form polymeric chains is not shared by SUMO-1, and although all SUMO species use the same conjugation machinery, modification by SUMo-1 andsumO-2/-3 may have distinct functional consequences.
Journal ArticleDOI
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
Michael H. Tatham,Marie-Claude Geoffroy,Linnan Shen,Anna Plechanovová,Neil Hattersley,Ellis Jaffray,Jorma J. Palvimo,Ronald T. Hay +7 more
TL;DR: It is demonstrated that poly-SUMO chains can act as discrete signals from mono-SumOylation, in this case targeting a poly- SUMOylated substrate for ubiquitin-mediated proteolysis.
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Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
TL;DR: The crystal structure of the dimeric RING domain of rat RNF4 in complex with E2 (UbcH5A) linked by an isopeptide bond to ubiquitin is reported, primed for catalysis as it can deprotonate the incoming substrate lysine residue and stabilize the consequent tetrahedral transition-state intermediate.
Journal ArticleDOI
Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional Activity
TL;DR: The reciprocal regulation of the activation and repressive activities are coupled by MAP kinase modification of Elk-1, and it is demonstrated that SUMO modification of the R motif is required for this repressive activity.
Journal ArticleDOI
A proteomic study of SUMO-2 target proteins.
Alfred C.O. Vertegaal,Stephen C. Ogg,Ellis Jaffray,Manuel S. Rodriguez,Ronald T. Hay,Jens S. Andersen,Matthias Mann,Angus I. Lamond +7 more
TL;DR: SART1 and heterogeneous nuclear RNP M were shown to be genuine SUMO targets, confirming the validity of the approach and eight novel potential SUMO-2 target proteins were identified by at least two peptides.