Ronald W. Alfa

TL;DR: A thorough behavioral phenotyping of the TS2-neo mouse is presented, suggesting that when TS mutant channels are expressed at levels low enough to avoid fatality, they are sufficient to cause multiple, distinct behavioral abnormalities, in line with the core aspects of ASD.

TL;DR: A genetic tool to measure insulin-like peptide 2 (Ilp2) levels in Drosophila, a model organism with superb experimental genetics, revealed a critical role for insulin signaling in specific peripheral tissues and found mechanisms and regulators controlling in vivo insulin dynamics should accelerate functional dissection of diabetes genetics.

TL;DR: Drosophila Limostatin is proposed as an index member of an ancient hormone class called decretins, which suppress insulin output and is expressed in islet β cells, and purified NMU suppresses insulin secretion from human islets.

TL;DR: Results from studies modeling metabolic disease in the fruit fly are examined and findings are compared to proposed mechanisms for diabetic phenotypes in mammals and a systematic framework for diabetes gene discovery in the fly is provided.

TL;DR: It is demonstrated for the first time that NGF delivery by lentiviral gene transfer using tetracycline-regulated promoters can completely regulate neuronal rescue and protein production in the brain.