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Armin Blesch
Researcher at Indiana University
Publications - 128
Citations - 12294
Armin Blesch is an academic researcher from Indiana University. The author has contributed to research in topics: Spinal cord injury & Spinal cord. The author has an hindex of 53, co-authored 127 publications receiving 11339 citations. Previous affiliations of Armin Blesch include University of California, Berkeley & United States Department of Veterans Affairs.
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Journal ArticleDOI
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Mark H. Tuszynski,Mark H. Tuszynski,Leon J. Thal,Leon J. Thal,Mary Pay,David P. Salmon,Hoi Sang U,Roy A.E. Bakay,Piyush M. Patel,Armin Blesch,H. Lee Vahlsing,H. Lee Vahlsing,Gilbert Ho,Gang Tong,Steven G. Potkin,James H. Fallon,Lawrence A. Hansen,Elliott J. Mufson,Jeffrey H. Kordower,Christine M. Gall,James M. Conner +20 more
TL;DR: A phase 1 trial of ex vivo NGF gene delivery in eight individuals with mild Alzheimer disease, implanting autologous fibroblasts genetically modified to express human NGF into the forebrain found no long-term adverse effects and brain autopsy from one subject suggested robust growth responses to NGF.
Journal ArticleDOI
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
Alan H. Nagahara,David A. Merrill,Giovanni Coppola,Shingo Tsukada,Brock E. Schroeder,Gideon M. Shaked,Ling Wang,Armin Blesch,Albert H. Kim,James M. Conner,Edward Rockenstein,Moses V. Chao,Edward H. Koo,Daniel H. Geschwind,Eliezer Masliah,Andrea A. Chiba,Mark H. Tuszynski,Mark H. Tuszynski +17 more
TL;DR: Broad neuroprotective effects of entorhinal brain-derived neurotrophic factor administration in several animal models of Alzheimer's disease are shown, with extension of therapeutic benefits into the degenerating hippocampus.
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A Neurovascular Niche for Neurogenesis after Stroke
TL;DR: A novel brain environment for neuronal regeneration after stroke is defined and molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury are identified.
Journal ArticleDOI
Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury
Paul Lu,Yaozhi Wang,Lori Graham,Karla McHale,Mingyong Gao,Di Wu,John H. Brock,Armin Blesch,Armin Blesch,Ephron S. Rosenzweig,Leif A. Havton,Binhai Zheng,James M. Conner,Martin Marsala,Mark H. Tuszynski,Mark H. Tuszynski +15 more
TL;DR: Property intrinsic to early-stage neurons can overcome the inhibitory milieu of the injured adult spinal cord to mount remarkable axonal growth, resulting in formation of new relay circuits that significantly improve function.
Journal ArticleDOI
Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury
TL;DR: Findings indicate that several spinal pathways contribute to loss of motor function after spinal cord injury, NT-3 is a neurotrophic factor for the injured corticospinal projection, and functional deficits are partially ameliorated by local cellular delivery ofNT-3.