Roncali L

TL;DR: Evidence is provided that dystrophin deficiency in mdx mice leads to disturbances in AQP4 assembly in the plasma membrane of fast skeletal muscle fibers and brain astrocytic end‐feet, suggesting that changes in the osmotic equilibrium of the neuromuscular apparatus may be involved in the pathology of muscular dystrophy.

TL;DR: This study confirms that leptin is angiogenic in vivo and suggests that, at least in the chick CAM, its activity is in part mediated by the activation of endogenous FGF-2.

TL;DR: These findings strongly suggest that FGF2 regulates the development of the capillary plexus by two sequential steps: in an early paracrine phase, chorionic epithelial cells secrete FGF1, thus eliciting an angiogenic response in the undifferentiated mesodermal blood vessels, and in a later phase, the newly formed endothelial cells move through a permissive ECM and migrate beneath the chorion.

TL;DR: The parallel formation of the astrocytic OAPs and the endothelial tight junctions further supports the suggestion that mutual relationships establish between perivascular glia and endothelium in the cerebral microvasculature differentiation during the blood-brain barrier development.

TL;DR: The results suggest that the pericytes are as active as the endothelial cells during the vessel growth and play an inhibitory role on the endotocyte proliferation only later on, when they are closely adherent to the endothelium and are encompassed by the basement lamina.