R
Rong-Jian Liu
Researcher at Yale University
Publications - 35
Citations - 7613
Rong-Jian Liu is an academic researcher from Yale University. The author has contributed to research in topics: Excitatory postsynaptic potential & NMDA receptor. The author has an hindex of 26, co-authored 33 publications receiving 6510 citations.
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Journal ArticleDOI
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Nanxin Li,Boyoung Lee,Rong-Jian Liu,Mounira Banasr,Jason M. Dwyer,Masaaki Iwata,Xiaoyuan Li,George K. Aghajanian,Ronald S. Duman +8 more
TL;DR: The results demonstrate that the effects of ketamine are opposite to the synaptic deficits that result from exposure to stress and could contribute to the fast antidepressant actions of ketamines.
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Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure.
Nanxin Li,Rong-Jian Liu,Jason M. Dwyer,Mounira Banasr,Boyoung Lee,Hyeon Son,Xiaoyuan Li,George K. Aghajanian,Ronald S. Duman +8 more
TL;DR: The results indicate that the structural and functional deficits resulting from long-term stress exposure, which could contribute to the pathophysiology of depression, are rapidly reversed by NMDA receptor antagonists in a mammalian target of rapamycin dependent manner.
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Signaling pathways underlying the rapid antidepressant actions of ketamine.
TL;DR: Together these studies indicate that ketamine rapidly reverses the atrophy of spines in the PFC and thereby causes a functional reconnection of neurons that underlies the rapid behavioral responses.
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Hypocretins (Orexins) Regulate Serotonin Neurons in the Dorsal Raphe Nucleus by Excitatory Direct and Inhibitory Indirect Actions
TL;DR: It is concluded that hcrts act directly to excite 5-HT neurons primarily via a TTX-insensitive, Na+/K+ nonselective cation current, and indirectly to activate local inhibitory GABA inputs to 5- HT cells.
Journal ArticleDOI
Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex.
Rong-Jian Liu,Francis S. Lee,Xiaoyuan Li,Francis Rodriguez Bambico,Ronald S. Duman,George K. Aghajanian +5 more
TL;DR: The results demonstrate that expression of the BDNF Met allele in mice results in basal synaptic deficits and blocks synaptogenic and antidepressant actions of ketamine in PFC, suggesting that the therapeutic response to this drug might be attenuated or blocked in depressed patients who carry the loss of function Met allele.