Rong Zhang

TL;DR: Testing the hypothesis that adolescent development is a stage of enhanced vulnerability to chronic stress shows that adolescent animals were protected from the effect of chronic stress on depression-like behavior while late adolescents animals were more susceptible to the somatic, HPA axis, and neuropeptide effects of Chronic stress.

TL;DR: IL-6 neurons of the HNS are a recruited component of the response to psychological stress, and data indicate that noninflammatory stressors selectively activate IL-6 magnocellular neurons, upregulate IL-8 gene expression in the PVN and SON, and increase plasma IL- 6.

TL;DR: Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLp-1 on adrenocorticotropin release.

TL;DR: Results reveal pronounced sex differences in the PVN GR dependence of acute stress feedback regulation of HPA axis function and indicate that glucocorticoid control of H PA axis responses after chronic stress operates via a PVN-independent mechanism.

TL;DR: It is suggested that glucocorticoids deplete the pool of transcribed PPG RNA and concurrently stimulate PPG gene transcription, with the latter allowing a mechanism for replenishment of PPG mRNA after stress cessation, resulting in a transient reduction in the capacity for neuropeptidergic excitation of stress responses.