R
Roopali Gandhi
Researcher at Brigham and Women's Hospital
Publications - 54
Citations - 4828
Roopali Gandhi is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Multiple sclerosis & T cell. The author has an hindex of 28, co-authored 49 publications receiving 3772 citations. Previous affiliations of Roopali Gandhi include Harvard University.
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Journal ArticleDOI
Alterations of the human gut microbiome in multiple sclerosis
Sushrut Jangi,Roopali Gandhi,Laura M. Cox,Ning Li,Felipe von Glehn,Raymond Yan,Bonny Patel,Maria Antonietta Mazzola,Shirong Liu,B. Glanz,Sandra Cook,Stephanie Tankou,Fiona Stuart,Kirsy Melo,Parham Nejad,Kathleen Smith,Begüm D. Topçuolu,James F. Holden,Pia Kivisäkk,Tanuja Chitnis,Philip L. De Jager,Francisco J. Quintana,Georg K. Gerber,Lynn Bry,Howard L. Weiner +24 more
TL;DR: Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes.
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The Host Shapes the Gut Microbiota via Fecal MicroRNA
Shirong Liu,Andre Pires da Cunha,Rafael M. Rezende,Ron Cialic,Zhiyun Wei,Lynn Bry,Laurie E. Comstock,Roopali Gandhi,Howard L. Weiner +8 more
TL;DR: It is shown that fecal microRNA-mediated inter-species gene regulation facilitates host control of the gut microbiota and a potential strategy for manipulating the microbiome is identified.
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Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3+ regulatory T cells
Roopali Gandhi,Deepak Kumar,Evan J Burns,Meghan Nadeau,Ben Dake,Alice Laroni,Alice Laroni,Deneen Kozoriz,Howard L. Weiner,Francisco J. Quintana +9 more
TL;DR: It is found that AhR activation promoted the differentiation of CD4+Foxp3− T cells, which produce IL-10 and control responder T cells through granzyme B, and is a potential target through which functional iTreg cells could be induced in human autoimmune disorders.
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Role of the innate immune system in the pathogenesis of multiple sclerosis
TL;DR: An overview of potential anti-inflammatory or pro-inflammatory function of DCs, microglial Cells, NK cells, NK-T cells and gamma delta T cells along with their interaction among themselves and with myelin is provided.
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Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25−LAP+ T cells
Hirofumi Ochi,Michal Abraham,Hiroki Ishikawa,Dan Frenkel,Kaiyong Yang,Alexandre S. Basso,Henry Wu,Mei-Ling Chen,Roopali Gandhi,Ariel Miller,Ruth Maron,Howard L. Weiner +11 more
TL;DR: It is found that orally administered CD3-specific antibody is biologically active in the gut and suppresses autoimmune encephalomyelitis both before induction of disease and at the height of disease.