F
Francisco J. Quintana
Researcher at Brigham and Women's Hospital
Publications - 281
Citations - 25163
Francisco J. Quintana is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 70, co-authored 256 publications receiving 18847 citations. Previous affiliations of Francisco J. Quintana include University of Seville & San Diego State University.
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Journal ArticleDOI
Control of T reg and T H 17 cell differentiation by the aryl hydrocarbon receptor
Francisco J. Quintana,Alexandre S. Basso,Antonio Iglesias,Thomas Korn,Mauricio F. Farez,Estelle Bettelli,Mario Caccamo,Mohamed Oukka,Howard L. Weiner +8 more
TL;DR: The identification of the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) as a regulator of Treg and TH17 cell differentiation in mice is reported, constituting a unique target for therapeutic immunomodulation.
Journal ArticleDOI
Induction and molecular signature of pathogenic TH17 cells
Youjin Lee,Amit Awasthi,Amit Awasthi,Nir Yosef,Nir Yosef,Francisco J. Quintana,Sheng Xiao,Anneli Peters,Chuan Wu,Markus Kleinewietfeld,Sharon R. Kunder,David A. Hafler,Raymond A. Sobel,Aviv Regev,Aviv Regev,Vijay K. Kuchroo +15 more
TL;DR: It is found that the production of TGF-β3 by developing Th17 cells was dependent on IL-23, which together with IL-6 induced very pathogenic TH17 cells, which had a molecular signature that defined pathogenic effector TH 17 cells in autoimmune disease.
Journal ArticleDOI
Alterations of the human gut microbiome in multiple sclerosis
Sushrut Jangi,Roopali Gandhi,Laura M. Cox,Ning Li,Felipe von Glehn,Raymond Yan,Bonny Patel,Maria Antonietta Mazzola,Shirong Liu,B. Glanz,Sandra Cook,Stephanie Tankou,Fiona Stuart,Kirsy Melo,Parham Nejad,Kathleen Smith,Begüm D. Topçuolu,James F. Holden,Pia Kivisäkk,Tanuja Chitnis,Philip L. De Jager,Francisco J. Quintana,Georg K. Gerber,Lynn Bry,Howard L. Weiner +24 more
TL;DR: Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes.
Journal ArticleDOI
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
Veit Rothhammer,Ivan D. Mascanfroni,Lukas Bunse,Maisa C. Takenaka,Jessica E. Kenison,Lior Mayo,Chun-Cheih Chao,Bonny Patel,Raymond Yan,Manon Blain,Jorge I. Alvarez,Hania Kebir,Niroshana Anandasabapathy,Guillermo Izquierdo,Steffen Jung,Nikolaus D. Obholzer,Nikolaus D. Obholzer,Nathalie Pochet,Nathalie Pochet,Clary B. Clish,Marco Prinz,Alexandre Prat,Jack P. Antel,Francisco J. Quintana +23 more
TL;DR: Findings suggest that IFN-Is produced in the CNS function in combination with metabolites derived from dietary tryptophan by the gut flora to activate AHR signaling in astrocytes and suppress CNS inflammation.
Journal ArticleDOI
Reactive astrocyte nomenclature, definitions, and future directions
Carole Escartin,Elena Galea,Andras Lakatos,James P. O'Callaghan,Gabor C. Petzold,Gabor C. Petzold,Alberto Serrano-Pozo,Christian Steinhäuser,Andrea Volterra,Giorgio Carmignoto,Giorgio Carmignoto,Amit Agarwal,Nicola J. Allen,Alfonso Araque,Luis Barbeito,Ari Barzilai,Dwight E. Bergles,Gilles Bonvento,Arthur M. Butt,Wei Ting Chen,Martine Cohen-Salmon,Colm Cunningham,Benjamin Deneen,Bart De Strooper,Bart De Strooper,Blanca Diaz-Castro,Cinthia Farina,Marc R. Freeman,Vittorio Gallo,James E. Goldman,Steven A. Goldman,Steven A. Goldman,Magdalena Götz,Antonia Gutierrez,Philip G. Haydon,Dieter Henrik Heiland,Elly M. Hol,Matthew Holt,Masamitsu Iino,Ksenia V. Kastanenka,Helmut Kettenmann,Baljit S. Khakh,Schuichi Koizumi,C. Justin Lee,Shane A. Liddelow,Brian A. MacVicar,Pierre J. Magistretti,Pierre J. Magistretti,Albee Messing,Anusha Mishra,Anna V. Molofsky,Keith K. Murai,Christopher M. Norris,Seiji Okada,Stéphane H. R. Oliet,João Filipe Oliveira,João Filipe Oliveira,Aude Panatier,Vladimir Parpura,Marcela Pekna,Milos Pekny,Luc Pellerin,Gertrudis Perea,Beatriz G. Pérez-Nievas,Frank W. Pfrieger,Kira E. Poskanzer,Francisco J. Quintana,Richard M. Ransohoff,Miriam Riquelme-Perez,Stefanie Robel,Christine R. Rose,Jeffrey D. Rothstein,Nathalie Rouach,David H. Rowitch,Alexey Semyanov,Alexey Semyanov,Swetlana Sirko,Harald Sontheimer,Raymond A. Swanson,Javier Vitorica,Ina B. Wanner,Levi B. Wood,Jia Qian Wu,Binhai Zheng,Eduardo R. Zimmer,Robert Zorec,Michael V. Sofroniew,Alexei Verkhratsky,Alexei Verkhratsky +88 more
TL;DR: In this article, the authors point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic vs-neuroprotective or A1-vs.A2.