L
Laura M. Cox
Researcher at Brigham and Women's Hospital
Publications - 79
Citations - 8479
Laura M. Cox is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Microbiome. The author has an hindex of 28, co-authored 51 publications receiving 6497 citations. Previous affiliations of Laura M. Cox include Harvard University & New York University.
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Journal ArticleDOI
Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences
Laura M. Cox,Shingo Yamanishi,Jiho Sohn,Alexander V. Alekseyenko,Jacqueline M. Leung,Ilseung Cho,Sungheon Kim,Huilin Li,Zhan Gao,Douglas Mahana,Jorge G. Zárate Rodriguez,Arlin B. Rogers,Nicolas Robine,P'ng Loke,Martin J. Blaser,Martin J. Blaser +15 more
TL;DR: It is shown that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects.
Journal ArticleDOI
Antibiotics in early life alter the murine colonic microbiome and adiposity
Ilseung Cho,Shingo Yamanishi,Laura M. Cox,Barbara A. Methé,Jiri Zavadil,Kelvin Li,Zhan Gao,Douglas Mahana,Kartik Raju,Isabel Teitler,Huilin Li,Alexander V. Alekseyenko,Martin J. Blaser +12 more
TL;DR: A model of adiposity is generated by giving subtherapeutic antibiotic therapy to young mice and changes in the composition and capabilities of the gut microbiome are evaluated, demonstrating the alteration of early-life murine metabolic homeostasis through antibiotic manipulation.
Journal ArticleDOI
Alterations of the human gut microbiome in multiple sclerosis
Sushrut Jangi,Roopali Gandhi,Laura M. Cox,Ning Li,Felipe von Glehn,Raymond Yan,Bonny Patel,Maria Antonietta Mazzola,Shirong Liu,B. Glanz,Sandra Cook,Stephanie Tankou,Fiona Stuart,Kirsy Melo,Parham Nejad,Kathleen Smith,Begüm D. Topçuolu,James F. Holden,Pia Kivisäkk,Tanuja Chitnis,Philip L. De Jager,Francisco J. Quintana,Georg K. Gerber,Lynn Bry,Howard L. Weiner +24 more
TL;DR: Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes.
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Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
Maria Gloria Dominguez-Bello,Maria Gloria Dominguez-Bello,Kassandra M. De Jesús-Laboy,Nan Shen,Laura M. Cox,Amnon Amir,Antonio Gonzalez,Nicholas A. Bokulich,Se Jin Song,Se Jin Song,Marina Hoashi,Juana I Rivera-Viñas,Keimari Mendez,Rob Knight,Jose C. Clemente +14 more
TL;DR: It is demonstrated that vaginal microbes can be partially restored at birth in C-section–delivered babies.
Journal ArticleDOI
Infant antibiotic exposures and early-life body mass
Leonardo Trasande,Jan Blustein,Mengling Liu,Elizabeth J. Corwin,Laura M. Cox,Martin J. Blaser +5 more
TL;DR: Exposure to antibiotics during the first 6 months of life is associated with consistent increases in body mass from 10 to 38 months, and further studies are needed to isolate effects and define life-course implications for body mass and cardiovascular risks.