Rory Kirchner

TL;DR: GEMINI (GEnome MINIng), a flexible software package for exploring all forms of human genetic variation, is developed, designed for reproducibility and flexibility, to provide researchers with a standard framework for medical genomics.

TL;DR: In this paper, the authors report transcripts whose abundances in human motor neurons are sensitive to TDP-43 depletion, and they propose that restoring STMN2 expression warrants examination as a therapeutic strategy for ALS.

TL;DR: This unbiased approach recovered most of the known intestinal stem cells/enteroblast and EE markers, and led to insights on intestinal stem cell biology, cell type-specific organelle features, the roles of new transcription factors in progenitors and regional variation along the gut, 5 additional EE gut hormones, EE hormonal expression diversity, and paracrine function of EEs.

TL;DR: It is reported that members of the four-pass transmembrane MS4A protein family are chemosensors expressed within necklace sensory neurons, which define a distinct mechanism and functional logic for mammalian olfaction.

TL;DR: Growth cone sorting and subcellular RNA–proteome mapping is developed, an approach that identifies and quantifies local transcriptomes and proteomes from labelled growth cones of single projections in vivo, and reveals subcellular relationships between local mRNA and local proteomes in developing projection neurons.