Brandi N. Davis-Dusenbery

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: Reprogramming and stem cell differentiation approaches with genome engineering and RNA sequencing are combined to define the transcriptional and functional changes that are induced in human motor neurons by mutant SOD1, indicating that at least a subset of these changes are more broadly conserved in ALS.

TL;DR: In this paper, the authors report transcripts whose abundances in human motor neurons are sensitive to TDP-43 depletion, and they propose that restoring STMN2 expression warrants examination as a therapeutic strategy for ALS.

TL;DR: The mechanisms that control the regulation of miRNA biogenesis discovered in human cells are reviewed and further understanding may allow the development of tools to modulate the expression of specific miRNAs, which is crucial for theDevelopment of novel therapies for human disorders derived from aberrant expression of mi RNAs.

TL;DR: It is demonstrated that TGF-β and BMP4 rapidly down-regulate KLF4 through induction of microRNA-143 (miR-143) and miR-145, which leads to a reduction of KLf4 transcripts and decreased KLF 4 protein expression.