F
Francesco Limone
Researcher at Harvard University
Publications - 14
Citations - 683
Francesco Limone is an academic researcher from Harvard University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 4, co-authored 8 publications receiving 325 citations. Previous affiliations of Francesco Limone include Royal Netherlands Academy of Arts and Sciences & Broad Institute.
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Journal ArticleDOI
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
Joseph R. Klim,Luis A. Williams,Francesco Limone,Irune Guerra San Juan,Brandi N. Davis-Dusenbery,Daniel A. Mordes,Aaron Burberry,Michael J. Steinbaugh,Kanchana K. Gamage,Rory Kirchner,Rob Moccia,Seth H. Cassel,Kuchuan Chen,Brian J. Wainger,Brian J. Wainger,Clifford J. Woolf,Kevin Eggan +16 more
TL;DR: In this paper, the authors report transcripts whose abundances in human motor neurons are sensitive to TDP-43 depletion, and they propose that restoring STMN2 expression warrants examination as a therapeutic strategy for ALS.
Journal ArticleDOI
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.
Aaron Burberry,Aaron Burberry,Michael F. Wells,Michael F. Wells,Francesco Limone,Francesco Limone,Francesco Limone,Alexander Couto,Alexander Couto,Kevin S. Smith,Kevin S. Smith,James Keaney,Gaëlle Gillet,Nick van Gastel,Jin-Yuan Wang,Jin-Yuan Wang,Olli Pietilainen,Olli Pietilainen,Menglu Qian,Menglu Qian,Pierce Eggan,Pierce Eggan,Christopher Cantrell,Christopher Cantrell,Joanie Mok,Joanie Mok,Irena Kadiu,David T. Scadden,Kevin Eggan,Kevin Eggan +29 more
TL;DR: Reduced abundance of immune-stimulating gut bacteria ameliorated the inflammatory and autoimmune phenotypes of mice with mutations in C9orf72, which in the human orthologue are linked to amyotrophic lateral sclerosis and frontotemporal dementia.
Journal ArticleDOI
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
Ralda Nehme,Ralda Nehme,Emanuela Zuccaro,Emanuela Zuccaro,Sulagna Ghosh,Sulagna Ghosh,Chenchen Li,John L. Sherwood,John L. Sherwood,Olli Pietilainen,Olli Pietilainen,Lindy E. Barrett,Lindy E. Barrett,Francesco Limone,Francesco Limone,Kathleen A. Worringer,Sravya Kommineni,Ying Zang,Davide Cacchiarelli,Alexander Meissner,Rolf Adolfsson,Stephen J. Haggarty,Jon M. Madison,Matthias Müller,Paola Arlotta,Paola Arlotta,Zhanyan Fu,Guoping Feng,Guoping Feng,Kevin Eggan,Kevin Eggan +30 more
TL;DR: Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an approach to generate human neurons for disease modeling as discussed by the authors, however, programming schemes produce a variety of cell types.
Journal ArticleDOI
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.
Daniel A. Mordes,Mercedes Prudencio,Lindsey D. Goodman,Joseph R. Klim,Joseph R. Klim,Rob Moccia,Francesco Limone,Francesco Limone,Olli Pietilainen,Olli Pietilainen,Kaitavjeet Chowdhary,Dennis W. Dickson,Rosa Rademakers,Nancy M. Bonini,Leonard Petrucelli,Kevin Eggan,Kevin Eggan +16 more
TL;DR: The results suggest that the expression of DPRs are associated with upregulation of HSF1 and activation of a heat shock response in C9ORF72-ALS/FTLD patients.
Journal ArticleDOI
Loss of mouse Stmn2 function causes motor neuropathy
Irune Guerra San Juan,Leslie A. Nash,Kevin S. Smith,Marcel F. Leyton-Jaimes,Menglu Qian,Joseph R. Klim,Francesco Limone,Alexander B. Dorr,Alexander Couto,Greta Pintacuda,Brian Joseph,Daniel Whisenant,Caroline F Noble,V. W. Melnik,Deirdre Potter,Amie L. Holmes,Aaron Phillip Burberry,Matthijs Verhage,Kevin Eggan +18 more
TL;DR: Guerra San Juan et al. as mentioned in this paper pointed out that the representative blots for the CNS Stmn2 protein levels in the F2 generation of Stmn 2 mutants included an incorrect duplicated blot for the GAPDH loading control in the brain samples.