R
Rosa M. C. Carmona
Researcher at University of Copenhagen
Publications - 2
Citations - 81
Rosa M. C. Carmona is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Protein–protein interaction & Thermal shift assay. The author has an hindex of 2, co-authored 2 publications receiving 43 citations.
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A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
Kim T. Tran,Jakob S. Pallesen,Sara Marie Øie Solbak,Dilip Narayanan,Amina Baig,Jie Zang,Alejandro Aguayo-Orozco,Rosa M. C. Carmona,Anthony D. Garcia,Anthony D. Garcia,Anders Bach +10 more
TL;DR: This study presents the first side-by-side assessment of all reported Keap1-Nrf2 PPI inhibitor classes using fluorescence polarization, thermal shift assay, and surface plasmon resonance and confirms the cross-assay activities for others.
Journal ArticleDOI
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Jakob S. Pallesen,Dilip Narayanan,Kim T. Tran,Sara Marie Øie Solbak,Giuseppe Marseglia,Giuseppe Marseglia,Louis M.E. Sørensen,Lars Jakobsen Høj,Federico Munafò,Rosa M. C. Carmona,Anthony D. Garcia,Anthony D. Garcia,Haritha L. Desu,Roberta Brambilla,Roberta Brambilla,Tommy N. Johansen,Grzegorz M Popowicz,Michael Sattler,Michael Gajhede,Anders Bach +19 more
TL;DR: In this paper, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays.