S
Sara Marie Øie Solbak
Researcher at University of Copenhagen
Publications - 26
Citations - 413
Sara Marie Øie Solbak is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Allosteric regulation & Chemistry. The author has an hindex of 11, co-authored 23 publications receiving 281 citations. Previous affiliations of Sara Marie Øie Solbak include Uppsala University & University of Bergen.
Papers
More filters
Journal ArticleDOI
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
Kim T. Tran,Jakob S. Pallesen,Sara Marie Øie Solbak,Dilip Narayanan,Amina Baig,Jie Zang,Alejandro Aguayo-Orozco,Rosa M. C. Carmona,Anthony D. Garcia,Anthony D. Garcia,Anders Bach +10 more
TL;DR: This study presents the first side-by-side assessment of all reported Keap1-Nrf2 PPI inhibitor classes using fluorescence polarization, thermal shift assay, and surface plasmon resonance and confirms the cross-assay activities for others.
Journal ArticleDOI
Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination.
Gabriel K. Pedersen,Katja Hoschler,Sara Marie Øie Solbak,Geir Bredholt,Rishi D. Pathirana,Aram Afsar,Lucy Breakwell,Jane Kristin Nøstbakken,Arnt J. Raae,Karl A. Brokstad,Haakon Sjursen,Maria Zambon,Rebecca Jane Cox,Rebecca Jane Cox +13 more
TL;DR: A phase I clinical trial of a virosomal H5N1 vaccine adjuvanted with the immunostimulating complex Matrix M™ found maturation of serum antibody avidity continued up to day 360 after influenza H5n1 vaccination, and virus neutralization correlated with serum H5 HA1-specific IgG antibody concentrations and not antibody avidy.
Journal ArticleDOI
HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein.
Sara Marie Øie Solbak,Tove Ragna Reksten,Friedrich Hahn,Victor Wray,Petra Henklein,Peter Henklein,Øyvind Halskau,Ulrich S. Schubert,Torgils Fossen +8 more
TL;DR: It is shown that p6 exhibits a defined structure with N- and C-terminal helical domains, connected by a flexible hinge region in 100mM dodecylphosphocholine micelle solution at pH 7 devoid of any organic co-solvents, indicating that this is a genuine limiting structural feature of the molecule in a hydrophobic environment.
Journal ArticleDOI
The dynamics of linear polyubiquitin.
Alexander Jussupow,Ana C. Messias,Ralf Stehle,Arie Geerlof,Sara Marie Øie Solbak,Cristina Paissoni,Anders Bach,Michael Sattler,Carlo Camilloni,Carlo Camilloni +9 more
TL;DR: A new approach to efficiently integrating small-angle x-ray scattering with simulations is introduced allowing researchers to accurately characterize the dynamics of linear di-, tri-, and tetraubiquitin in the free state as well as of diubiquItin in complex with NEMO, a central regulator in the NF-κB pathway.
Journal ArticleDOI
Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly
Jörg Votteler,Liane Neumann,Sabine Hahn,Friedrich Hahn,Pia Rauch,Kerstin Schmidt,Nicole Studtrucker,Sara Marie Øie Solbak,Torgils Fossen,Peter Henklein,David E. Ott,Gudrun Holland,Norbert Bannert,Ulrich S. Schubert +13 more
TL;DR: A so far unrecognized function of p6 mediated by Ser-40 that occurs independently of the L-domain function, but selectively affects CA maturation and virus core formation, and consequently the infectivity of released virions is supported.