R
Rosa Mistica C. Ignacio
Researcher at Meharry Medical College
Publications - 23
Citations - 413
Rosa Mistica C. Ignacio is an academic researcher from Meharry Medical College. The author has contributed to research in topics: Proinflammatory cytokine & Cancer. The author has an hindex of 11, co-authored 22 publications receiving 299 citations. Previous affiliations of Rosa Mistica C. Ignacio include Yonsei University.
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Journal ArticleDOI
Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge.
Cheol-Su Kim,Hai Duong Nguyen,Rosa Mistica C. Ignacio,Jae Hyun Kim,Hyeon Cheol Cho,Eun Ho Maeng,Yu Ri Kim,Meyoung Kon Kim,Bae Keun Park,Soo Ki Kim +9 more
TL;DR: The results indicate that different sized and charged ZnO NPs would cause in vitro and in vivo immunotoxicity, of which nature is an immunosuppression.
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Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge
Jae Hyun Kim,Cheol-Su Kim,Rosa Mistica C. Ignacio,Dong Heui Kim,Ma Easter Joy Sajo,Eun Ho Maeng,Xu Feng Qi,Seong Eun Park,Yu Ri Kim,Meyoung Kon Kim,Kyu-Jae Lee,Soo Ki Kim +11 more
TL;DR: Interestingly, the small-sized and negatively charged SiO2 NPs showed the most potent in vivo immunotoxicity by way of suppressing the proliferation of lymphocytes, depressing the killing activity of NK cells, and decreasing proinflammatory cytokine production, thus leading to immunosuppression.
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Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer.
Rosa Mistica C. Ignacio,Eun Sook Lee,Andrew J. Wilson,Alicia Beeghly-Fadiel,Margaret M. Whalen,Deok-Soo Son +5 more
TL;DR: Associations between chemokine expression and survival in tumor suppressor protein p53 (TP53) wild-type ( TP53WT) and mutant (TP 53m) OC datasets are evaluated to identify specific chemokines that differentially influence OS in TP53 WT and TP53m OC.
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Serum amyloid A predisposes inflammatory tumor microenvironment in triple negative breast cancer.
Rosa Mistica C. Ignacio,Carla R. Gibbs,Soo-Hyun Kim,Eun Sook Lee,Samuel E. Adunyah,Deok-Soo Son +5 more
TL;DR: IL-1-induced SAA via NF-κB-mediated signaling could potentiate an inflammatory burden, leading to cancer progression and high mortality in TNBC patients, and SAA1/2, TLR2 and IL8/CXCL8 were associated with a poor overall survival in mesenchymal-like TNBC.
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NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression.
TL;DR: The progression of ovarian cancer in the peritoneal cavity involves NF-κB-mediated CCL20 as a main chemokine network, which is potentiated by CXCR2 expression, and dominant chemokines expressed in ovarian tumor tissues are likely shifted from CXCL1-3 and 8 to CCL 20.