A
Alicia Beeghly-Fadiel
Researcher at Vanderbilt University Medical Center
Publications - 113
Citations - 3771
Alicia Beeghly-Fadiel is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 25, co-authored 94 publications receiving 3028 citations. Previous affiliations of Alicia Beeghly-Fadiel include Oulu University Hospital & Erasmus University Rotterdam.
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Journal ArticleDOI
RAD51B in Familial Breast Cancer
Liisa M. Pelttari,Sofia Khan,Mikko Vuorela,Johanna I. Kiiski,Sara Vilske,Viivi Nevanlinna,Salla Ranta,Johanna Schleutker,Johanna Schleutker,Johanna Schleutker,Robert Winqvist,Anne Kallioniemi,Thilo Dörk,Natalia Bogdanova,Jonine Figueroa,Paul D.P. Pharoah,Marjanka K. Schmidt,Alison M. Dunning,Montserrat Garcia-Closas,Manjeet K. Bolla,Joe Dennis,Kyriaki Michailidou,Qin Wang,John L. Hopper,Melissa C. Southey,Efraim H. Rosenberg,Peter A. Fasching,Peter A. Fasching,Matthias W. Beckmann,Julian Peto,Isabel dos-Santos-Silva,Elinor J. Sawyer,Ian Tomlinson,Barbara Burwinkel,Barbara Burwinkel,Harald Surowy,Harald Surowy,Pascal Guénel,Thérèse Truong,Stig E. Bojesen,Stig E. Bojesen,Børge G. Nordestgaard,Børge G. Nordestgaard,Javier Benitez,Anna González-Neira,Susan L. Neuhausen,Hoda Anton-Culver,Hermann Brenner,Volker Arndt,Alfons Meindl,Rita K. Schmutzler,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Annika Lindblom,Sara Margolin,Arto Mannermaa,Jaana M. Hartikainen,Georgia Chenevix-Trench,kConFab,kConFab,Aocs Investigators,Laurien Van Dyck,Hilde Janssen,Hilde Janssen,Jenny Chang-Claude,Anja Rudolph,Paolo Radice,Paolo Peterlongo,Emily Hallberg,Janet E. Olson,Janet E. Olson,Graham G. Giles,Graham G. Giles,Roger L. Milne,Christopher A. Haiman,Fredrick Schumacher,Jacques Simard,Martine Dumont,Martine Dumont,Vessela N. Kristensen,Vessela N. Kristensen,Anne Lise Børresen-Dale,Wei Zheng,Alicia Beeghly-Fadiel,Mervi Grip,Mervi Grip,Irene L. Andrulis,Gord Glendon,Peter Devilee,Caroline Seynaeve,Maartje J. Hooning,Margriet Collée,Angela Cox,Simon S. Cross,Mitul Shah,Robert Luben,Ute Hamann,Ute Hamann,Diana Torres,Anna Jakubowska,Jan Lubinski,Fergus J. Couch,Drakoulis Yannoukakos,Nick Orr,Anthony J. Swerdlow,Hatef Darabi,Jingmei Li,Kamila Czene,Per Hall,Douglas F. Easton,Johanna Mattson,Carl Blomqvist,Kristiina Aittomäki,Heli Nevanlinna +115 more
TL;DR: It is suggested that loss-of-function mutations in RAD 51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.
Journal ArticleDOI
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Felix R. Day,Katherine S. Ruth,Deborah J. Thompson,Kathryn L. Lunetta,Natalia Pervjakova,Daniel I. Chasman,Lisette Stolk,Hilary K. Finucane,Patrick Sulem,Brendan Bulik-Sullivan,Tõnu Esko,Andrew D. Johnson,Cathy E. Elks,Nora Franceschini,Chunyan He,Elisabeth Altmaier,Jennifer A. Brody,Lude Franke,Jennifer E. Huffman,Margaux F. Keller,Patrick F. McArdle,Teresa Nutile,Eleonora Porcu,Antonietta Robino,Lynda M. Rose,Ursula M. Schick,Jennifer A. Smith,Alexander Teumer,Michela Traglia,Dragana Vuckovic,Jie Yao,Wei Zhao,Eva Albrecht,Najaf Amin,Tanguy Corre,Jouke-Jan Hottenga,Massimo Mangino,Albert V. Smith,Toshiko Tanaka,Goncąlo R. Abecasis,Irene L. Andrulis,Hoda Anton-Culver,Antonis C. Antoniou,Volker Arndt,Alice M. Arnold,Caterina Barbieri,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Leslie Bernstein,Suzette J. Bielinski,Carl Blomqvist,Eric Boerwinkle,Natalia Bogdanova,S.E. Bojesen,Manjeet K. Bolla,Anne Lise Børresen-Dale,Thibaud Boutin,Hiltrud Brauch,Hermann Brenner,Thomas Brüning,Barbara Burwinkel,Archie Campbell,Harry Campbell,Stephen J. Chanock,J. Ross Chapman,Yii-Der Ida Chen,Georgia Chenevix-Trench,Fergus J. Couch,Andrea D. Coviello,Angela Cox,Kamila Czene,Hatef Darabi,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Peter Devilee,Thilo Dörk,Isabel dos-Santos-Silva,Alison M. Dunning,John D. Eicher,P. A. Fasching,Jessica D. Faul,Jonine D. Figueroa,Dieter Flesch-Janys,Ilaria Gandin,Melissa E. Garcia,Montserrat Garcia-Closas,Graham G. Giles,Giorgia Girotto,Mark S. Goldberg,Anna González-Neira,Mark O. Goodarzi,Megan L. Grove,D. F. Gudbjartsson,Pascal Guenel,Xiuqing Guo,Christopher A. Haiman,Per Hall,U Hamann,Brian E. Henderson,Lynne J. Hocking,Albert Hofman,Georg Homuth,Maartje J. Hooning,John L. Hopper,Frank B. Hu,Jinyan Huang,Keith Humphreys,David J. Hunter,Anna Jakubowska,Samuel E. Jones,Maria Kabisch,David Karasik,Julia A. Knight,Ivana Kolcic,Charles Kooperberg,Veli-Matti Kosma,Jennifer Kriebel,Vessela N. Kristensen,Diether Lambrechts,Claudia Langenberg,Jingmei Li,Xin Li,Sara Lindström,Yongmei Liu,Jian'an Luan,Jan Lubinski,Reedik Mägi,Arto Mannermaa,Judith Manz,Sara Margolin,Jonathan Marten,Nicholas G. Martin,Corrado Masciullo,A. Meindl,Kyriaki Michailidou,E. Mihailov,Lili Milani,Roger L. Milne,Martina Müller-Nurasyid,Mike A. Nalls,Benjamin M. Neale,Benjamin M. Neale,Heli Nevanlinna,Patrick Neven,Anne B. Newman,Børge G. Nordestgaard,Janet E. Olson,Sandosh Padmanabhan,Paolo Peterlongo,Ulrike Peters,Astrid Petersmann,Julian Peto,Paul D.P. Pharoah,Nicola Pirastu,Ailith Pirie,Giorgio Pistis,Ozren Polasek,David J. Porteous,Bruce M. Psaty,Katri Pylkäs,Paolo Radice,Leslie J. Raffel,Fernando Rivadeneira,Igor Rudan,Anja Rudolph,Daniela Ruggiero,Cinzia Sala,Serena Sanna,Elinor J. Sawyer,David Schlessinger,Marjanka K. Schmidt,Frank Schmidt,Rita K. Schmutzler,Minouk J. Schoemaker,Robert A. Scott,Caroline Seynaeve,Jacques Simard,Rossella Sorice,Melissa C. Southey,Doris Stöckl,Konstantin Strauch,Anthony J. Swerdlow,Kent D. Taylor,Unnur Thorsteinsdottir,Amanda E. Toland,Ian Tomlinson,Thérèse Truong,Laufey Tryggvadottir,Stephen Turner,Diego Vozzi,Qin Wang,Melissa Wellons,Gonneke Willemsen,James F. Wilson,Robert Winqvist,Bruce H. R. Wolffenbuttel,A. F. Wright,Drakoulis Yannoukakos,Tatijana Zemunik,Wei Zheng,Marek Zygmunt,Sven Bergmann,Dorret I. Boomsma,Julie E. Buring,Luigi Ferrucci,Grant W. Montgomery,Vilmundur Gudnason,Tim D. Spector,Cornelia M. van Duijn,Behrooz Z. Alizadeh,Marina Ciullo,Laura Crisponi,Douglas F. Easton,Paolo Gasparini,Christian Gieger,Tamara B. Harris,Caroline Hayward,Sharon L.R. Kardia,Peter Kraft,Barbara McKnight,Andres Metspalu,Alanna C. Morrison,Alexander P. Reiner,Paul M. Ridker,Jerome I. Rotter,Daniela Toniolo,André G. Uitterlinden,Sheila Ulivi,Henry Völzke,Nicholas J. Wareham,David R. Weir,Laura M. Yerges-Armstrong,Alkes L. Price,Kari Stefansson,Jenny A. Visser,Ken K. Ong,Jenny Chang-Claude,Joanne M. Murabito,John R. B. Perry,Anna Murray +241 more
TL;DR: A dual strategy to identify common and low-frequency protein-coding variation associated with age at natural menopause and enrichment of signals in or near genes involved in delayed puberty are reported, highlighting the first molecular links between the onset and end of reproductive lifespan.
Journal ArticleDOI
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Catherine M. Phelan,Karoline Kuchenbaecker,Karoline Kuchenbaecker,Jonathan Tyrer,Siddhartha Kar,Kate Lawrenson,Stacey J. Winham,Joe Dennis,Ailith Pirie,Marjorie J. Riggan,Ganna Chornokur,Madalene Earp,Paulo C Lyra,Janet M. Lee,Simon G. Coetzee,Jonathan Beesley,Lesley McGuffog,Penny Soucy,Ed Dicks,Andrew Lee,Daniel Barrowdale,Julie Lecarpentier,Goska Leslie,Cora M. Aalfs,Katja K.H. Aben,Marcia Adams,Julian Adlard,Irene L. Andrulis,Irene L. Andrulis,Hoda Anton-Culver,Natalia Antonenkova,Gerasimos Aravantinos,Norbert Arnold,Banu Arun,Brita Arver,Jacopo Azzollini,Judith Balmaña,Susana Banerjee,Laure Barjhoux,Rosa B. Barkardottir,Yukie Bean,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Marina Bermisheva,Marcus Q. Bernardini,Michael J. Birrer,Line Bjørge,Line Bjørge,Amanda Black,Kenneth Blankstein,Marinus J. Blok,Clara Bodelon,Natalia Bogdanova,Anders Bojesen,Bernardo Bonanni,Åke Borg,Angela R. Bradbury,James D. Brenton,Carole Brewer,Louise A. Brinton,Per Broberg,Angela Brooks-Wilson,Fiona Bruinsma,Joan Brunet,Bruno Buecher,Ralf Bützow,Saundra S. Buys,Trinidad Caldés,Maria A. Caligo,Ian G. Campbell,Ian G. Campbell,Rikki Cannioto,Michael E. Carney,Terence Cescon,Salina B. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Xiaoqing Chen,Yoke-Eng Chiew,Yoke-Eng Chiew,Jocelyne Chiquette,Wendy K. Chung,Kathleen Claes,Thomas Conner,Linda S. Cook,Jackie Cook,Daniel W. Cramer,Julie M. Cunningham,Aimee A D'Aloisio,Mary B. Daly,Francesca Damiola,Sakaeva Dina Damirovna,Agnieszka Dansonka-Mieszkowska,Fanny Dao,Rosemarie Davidson,Anna deFazio,Anna deFazio,Capucine Delnatte,Kimberly F. Doheny,Orland Diez,Yuan Chun Ding,Jennifer A. Doherty,Susan M. Domchek,Cecilia M. Dorfling,Thilo Dörk,Laure Dossus,Mercedes Durán,Matthias Dürst,Bernd Dworniczak,Diana Eccles,Todd L. Edwards,Ros Eeles,Ursula Eilber,Bent Ejlertsen,Arif B. Ekici,Steve Ellis,Mingajeva Elvira,Kevin H. Eng,Christoph Engel,D. Gareth Evans,Peter A. Fasching,Peter A. Fasching,Sarah E. Ferguson,Sandra Fert Ferrer,James M. Flanagan,Zachary C. Fogarty,Renée T. Fortner,Florentia Fostira,William D. Foulkes,George Fountzilas,Brooke L. Fridley,Tara M. Friebel,Eitan Friedman,Eitan Friedman,Debra Frost,Patricia A. Ganz,Judy Garber,María Josefa Mosteiro García,Vanesa García-Barberán,Andrea Gehrig,Aleksandra Gentry-Maharaj,Anne-Marie Gerdes,Graham G. Giles,Graham G. Giles,Graham G. Giles,Rosalind Glasspool,Gord Glendon,Andrew K. Godwin,David E. Goldgar,Teodora Goranova,Martin Gore,Mark H. Greene,Jacek Gronwald,Stephen B. Gruber,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,Thomas Hansen,Patricia Harrington,Holly R. Harris,Jan Hauke,Alexander Hein,Alex Henderson,Michelle A.T. Hildebrandt,Peter Hillemanns,Shirley Hodgson,Claus Høgdall,Estrid Høgdall,Frans B. L. Hogervorst,Helene Holland,Maartje J. Hooning,Karen Hosking,Ruea-Yea Huang,Peter J. Hulick,Jillian Hung,Jillian Hung,David J. Hunter,David G. Huntsman,Tomasz Huzarski,Evgeny N. Imyanitov,Claudine Isaacs,Edwin S. Iversen,Louise Izatt,Angel Izquierdo,Anna Jakubowska,Paul A. James,Paul A. James,Ramunas Janavicius,Mats Jernetz,Allan Jensen,Uffe Birk Jensen,Esther M. John,Sharon E. Johnatty,Michael Jones,Päivi Kannisto,Beth Y. Karlan,Anthony N. Karnezis,Karin Kast,Catherine J. Kennedy,Catherine J. Kennedy,Elza Khusnutdinova,Lambertus A. Kiemeney,Johanna I. Kiiski,Sung-Won Kim,Susanne K. Kjaer,Martin Köbel,Reidun K. Kopperud,Reidun K. Kopperud,Torben A Kruse,Jolanta Kupryjanczyk,Ava Kwong,Yael Laitman,Yael Laitman,Diether Lambrechts,Nerea Larrañaga,Melissa C. Larson,Conxi Lázaro,Nhu D. Le,Loic Le Marchand,Jong Won Lee,Shashikant Lele,Arto Leminen,Dominique Leroux,Jenny Lester,Fabienne Lesueur,Fabienne Lesueur,Douglas A. Levine,Dong Liang,Clemens Liebrich,Jenna Lilyquist,Loren Lipworth,Jolanta Lissowska,Karen H. Lu,Jan Lubinński,Craig Luccarini,Lene Lundvall,Phuong L. Mai,Gustavo Mendoza-Fandiño,Siranoush Manoukian,Leon F.A.G. Massuger,Taymaa May,Sylvie Mazoyer,Jessica N. McAlpine,Valerie McGuire,John R. McLaughlin,Iain A. McNeish,Hanne Meijers-Heijboer,Alfons Meindl,Usha Menon,Arjen R. Mensenkamp,Melissa A. Merritt,Roger L. Milne,Roger L. Milne,Gillian Mitchell,Gillian Mitchell,Francesmary Modugno,Joanna Moes-Sosnowska,Melissa Moffitt,Marco Montagna,Kirsten B. Moysich,Anna Marie Mulligan,Anna Marie Mulligan,Jacob Musinsky,Katherine L. Nathanson,Lotte Nedergaard,Roberta B. Ness,Susan L. Neuhausen,Heli Nevanlinna,Dieter Niederacher,Robert L. Nussbaum,Kunle Odunsi,Edith Olah,Olufunmilayo I. Olopade,Håkan Olsson,Curtis Olswold,David M. O'Malley,Kai-ren Ong,N. Charlotte Onland-Moret,Nick Orr,Sandra Orsulic,Ana Osorio,Domenico Palli,Laura Papi,Tjoung-Won Park-Simon,James Paul,Celeste Leigh Pearce,Celeste Leigh Pearce,Inge Søkilde Pedersen,Petra H.M. Peeters,Bernard Peissel,Ana Peixoto,Tanja Pejovic,Liisa M. Pelttari,Jennifer B. Permuth,Paolo Peterlongo,Lidia Pezzani,Georg Pfeiler,Kelly-Anne Phillips,Kelly-Anne Phillips,Marion Piedmonte,Malcolm C. Pike,Malcolm C. Pike,Anna M. Piskorz,Samantha Poblete,Timea Pocza,Elizabeth M. Poole,Bruce Poppe,Mary Porteous,Fabienne Prieur,Darya Prokofyeva,Elizabeth W. Pugh,Miquel Angel Pujana,Pascal Pujol,Paolo Radice,Johanna Rantala,Christine Rappaport-Fuerhauser,Gad Rennert,Kerstin Rhiem,Patricia Rice,Andrea L. Richardson,Mark E. Robson,Gustavo C. Rodriguez,Cristina Rodríguez-Antona,Jane Romm,Matti A. Rookus,Mary Anne Rossing,Joseph H. Rothstein,Anja Rudolph,Ingo B. Runnebaum,Helga B. Salvesen,Helga B. Salvesen,Dale P. Sandler,Minouk J. Schoemaker,Leigha Senter,V. Wendy Setiawan,Gianluca Severi,Priyanka Sharma,Tameka Shelford,Nadeem Siddiqui,Lucy Side,Weiva Sieh,Christian F. Singer,Hagay Sobol,Honglin Song,Melissa C. Southey,Amanda B. Spurdle,Zsofia K. Stadler,Doris Steinemann,Dominique Stoppa-Lyonnet,Lara E. Sucheston-Campbell,Grzegorz Sukiennicki,Rebecca Sutphen,Christian Sutter,Anthony J. Swerdlow,Anthony J. Swerdlow,Csilla Szabo,Lukasz Szafron,Yen Y. Tan,Jack A. Taylor,Muy-Kheng Tea,Manuel R. Teixeira,Soo Hwang Teo,Kathryn L. Terry,Kathryn L. Terry,Pamela J. Thompson,Liv Cecilie Vestrheim Thomsen,Liv Cecilie Vestrheim Thomsen,Darcy L. Thull,Laima Tihomirova,Anna V. Tinker,Marc Tischkowitz,Silvia Tognazzo,Amanda E. Toland,Alicia A. Tone,Britton Trabert,Ruth C. Travis,Antonia Trichopoulou,Nadine Tung,Shelley S. Tworoger,Shelley S. Tworoger,Anne M. van Altena,David Van Den Berg,Annemarie H. van der Hout,Rob B. van der Luijt,Mattias Van Heetvelde,Els Van Nieuwenhuysen,Elizabeth J. van Rensburg,Adriaan Vanderstichele,Raymonda Varon-Mateeva,Ana Vega,Digna R. Velez Edwards,Digna R. Velez Edwards,Ignace Vergote,Robert A. Vierkant,Joseph Vijai,Athanassios Vratimos,Lisa Walker,Christine Walsh,Dorothea Wand,Shan Wang-Gohrke,Barbara Wappenschmidt,Penelope M. Webb,Clarice R. Weinberg,Jeffrey N. Weitzel,Nicolas Wentzensen,Alice S. Whittemore,Juul T. Wijnen,Lynne R. Wilkens,Alicja Wolk,Michelle M.M. Woo,Xifeng Wu,Anna H. Wu,Hannah P. Yang,Drakoulis Yannoukakos,Argyrios Ziogas,Kristin K. Zorn,Steven A. Narod,Douglas F. Easton,Christopher I. Amos,Joellen M. Schildkraut,Susan J. Ramus,Susan J. Ramus,Laura Ottini,Marc T. Goodman,Sue K. Park,Linda E. Kelemen,Harvey A. Risch,Mads Thomassen,Kenneth Offit,Jacques Simard,Rita K. Schmutzler,Dennis J. Hazelett,Alvaro N.A. Monteiro,Fergus J. Couch,Andrew Berchuck,Georgia Chenevix-Trench,Ellen L. Goode,Thomas A. Sellers,Simon A. Gayther,Antonis C. Antoniou,Paul D.P. Pharoah +443 more
TL;DR: Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Journal ArticleDOI
Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence
TL;DR: Whereas most genetic variants assessed in previous candidate-gene studies showed no association with breast-cancer risk in meta-analyses, 14 variants in nine genes had moderate to strong evidence for an association.
Journal ArticleDOI
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.
Yan Guo,Shaneda Warren Andersen,Xiao-Ou Shu,Kyriaki Michailidou,Manjeet K. Bolla,Qin Wang,Montserrat Garcia-Closas,Roger L. Milne,Roger L. Milne,Marjanka K. Schmidt,Jenny Chang-Claude,Jenny Chang-Claude,Allison M Dunning,Stig E. Bojesen,Habibul Ahsan,Kristiina Aittomäki,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Natalia Bogdanova,Bernardo Bonanni,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Thomas Brüning,Barbara Burwinkel,Graham Casey,Georgia Chenevix-Trench,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Peter Devilee,Thilo Dörk,Martine Dumont,Peter A. Fasching,Peter A. Fasching,Jonine Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Florentia Fostira,Marilie D. Gammon,Graham G. Giles,Graham G. Giles,Pascal Guénel,Christopher A. Haiman,Ute Hamann,Maartje J. Hooning,John L. Hopper,Anna Jakubowska,Farzana Jasmine,Mark A. Jenkins,Esther M. John,Esther M. John,Nichola Johnson,Michael Jones,Maria Kabisch,Muhammad G. Kibriya,Julia A. Knight,Linetta B. Koppert,Veli-Matti Kosma,Vessela N. Kristensen,Loic Le Marchand,Eunjung Lee,Jingmei Li,Annika Lindblom,Robert Luben,Jan Lubinski,Kathi Malone,Arto Mannermaa,Sara Margolin,Frederik Marmé,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Janet E. Olson,Jose Ignacio Arias Perez,Barbara Perkins,Paolo Peterlongo,Kelly-Anne Phillips,Katri Pylkäs,Anja Rudolph,Regina M. Santella,Elinor J. Sawyer,Rita K. Schmutzler,Caroline Seynaeve,Mitul Shah,Martha J. Shrubsole,Melissa C. Southey,Anthony J. Swerdlow,Amanda E. Toland,Ian Tomlinson,Diana Torres,Thérèse Truong,Giske Ursin,Rob B. van der Luijt,Senno Verhoef,Alice S. Whittemore,Robert Winqvist,Hui Zhao,Shilin Zhao,Per Hall,Jacques Simard,Peter Kraft,Paul D.P. Pharoah,David J. Hunter,Douglas F. Easton,Wei Zheng +117 more
TL;DR: BMI predicted by genome-wide association studies (GWAS)-identified variants is inversely associated with the risk of both pre- and postmenopausal breast cancer, differs from the positive association reported from studies using measured adult BMI.