Rosana Collepardo-Guevara

TL;DR: In this paper, the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4, Sox2, and Annexin A11, can reenter a phase-separated regime at high salt concentrations.

TL;DR: The results indicate that the previous assessment of the accuracy of the RPMD approximation for atom-diatom reactions remains valid for more complex polyatomic reactions, and suggest that the sensitivity of the QTST and QI rate coefficients to the choice of the transition state dividing surface becomes more of an issue as the dimensionality of the reaction increases.

TL;DR: The physical parameters dictating the stability and composition of multicomponent biomolecular condensates are investigated using a minimal coarse-grained model and it is demonstrated that the molecular connectivity of the condensed-liquid network determines the stability (e.g., in temperature, pH, salt concentration), where stability is positively correlated with connectivity.

TL;DR: An efficient procedure for calculating the rates of bimolecular chemical reactions in the gas phase within the ring polymer molecular dynamics approximation, which is illustrated with applications to the three-dimensional H + H(2), Cl + HCl, and F + H

TL;DR: It is shown that proteins implicated in cellular LLPS, including FUS, TDP-43, Brd4, Sox2, and Annexin A11, which form condensates at low salt concentrations, can reenter a phase-separated regime at high salt concentrations.