R
Rosaria Varì
Researcher at Istituto Superiore di Sanità
Publications - 55
Citations - 4025
Rosaria Varì is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 25, co-authored 51 publications receiving 3522 citations.
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Journal ArticleDOI
Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes.
TL;DR: The latest studies strongly suggest that dietary polyphenols can stimulate antioxidant transcription and detoxification defense systems through AREs present in the promoter regions of many of the genes inducible by oxidative and chemical stress.
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Bioavailability of the polyphenols: status and controversies.
TL;DR: In the present review, a critical overview on the difficulties and the controversies of the studies on the bioavailability of the polyphenols is discussed.
Journal Article
Polyphenols, intracellular signalling and inflammation
Carmela Santangelo,Rosaria Varì,Beatrice Scazzocchio,Roberta Di Benedetto,Carmela Filesi,Roberta Masella +5 more
TL;DR: This review will discuss recent data on the control of inflammatory signalling exerted by some dietary polyphenols contained in Mediterranean diet.
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Cyanidin-3-O-β-Glucoside and Protocatechuic Acid Exert Insulin-Like Effects by Upregulating PPARγ Activity in Human Omental Adipocytes
Beatrice Scazzocchio,Rosaria Varì,Carmelina Filesi,Massimo D'Archivio,Carmela Santangelo,Claudio Giovannini,Annunziata Iacovelli,Gianfranco Silecchia,Giovanni Li Volti,Fabio Galvano,Roberta Masella +10 more
TL;DR: Evidence is provided that C3G and PCA might exert insulin-like activities by PPARγ activation, evidencing a causal relationship between this transcription factor and adiponectin and GLUT4 upregulation.
Journal ArticleDOI
Extra Virgin Olive Oil Biophenols Inhibit Cell-Mediated Oxidation of LDL by Increasing the mRNA Transcription of Glutathione-Related Enzymes
Roberta Masella,Rosaria Varì,Massimo D'Archivio,Roberta Di Benedetto,Paola Matarrese,Walter Malorni,Beatrice Scazzocchio,Claudio Giovannini +7 more
TL;DR: The mechanisms underlying the protective effect exerted by extra virgin olive oil biophenols, namely, protocatechuic acid and oleuropein, on LDL oxidation mediated by murine J774 A.1 macrophage-like cells are investigated and the activation of mRNA transcription of GSH-related enzymes represents an important mechanism in phenolic antioxidant action.