Rosario Donato

TL;DR: The present data suggest that annexin VI might regulate S100A1 and S100B activities and vice versa, and no effects of annexin V on the ability of S 100A1 or S 100B to affect the desmin and GFAP assemblies could be documented, although binding of annexIn V to S100a1 andS100B could be detected at relatively high Ca2+ concentrations.

TL;DR: Findings point to a relevant role of the danger sensing signaling in human antifungal immunity and highlight a possible contribution of a genetically-determined hyperfunction of the S100B/RAGE axis to susceptibility to IA in the HSCT setting.

TL;DR: It is suggested that exposure of acute hippocampal slices to low- and high-K+ could be used as an assay to evaluate astrocyte activity by S100B secretion: positively regulated by low K+ (possibly involving mobilization of internal stores of Ca2+) and negatively regulated by high-k+ (likely secondary to influx of K+).

TL;DR: It is proposed that S100B is a danger signal released from injured muscles that participates in skeletal muscle regeneration by activating the promyogenic RAGE or the mitogenic bFGF/FGFR1 depending on its own concentration, the absence or presence of bF GF, and myoblast density.

TL;DR: Observations suggest that S100A1 and S100B may be regarded as Ca2+-dependent regulators of the state of assembly of two important elements of the cytoskeleton, IFs and MTs, and, potentially, of MT- and IF-based activities.