R
Rosario Donato
Researcher at University of Perugia
Publications - 166
Citations - 14643
Rosario Donato is an academic researcher from University of Perugia. The author has contributed to research in topics: RAGE (receptor) & Myocyte. The author has an hindex of 51, co-authored 166 publications receiving 12919 citations.
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Journal ArticleDOI
S100B and S100A1 proteins in bovine retina:their calcium-dependent stimulation of a membrane-bound guanylate cyclase activity as investigated by ultracytochemistry.
TL;DR: The data suggest that at least S100B may take part in the regulation of a membrane-bound guanylate cyclase-based signalling pathway in both photoreceptors and Muller cells.
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Mechanism of action of S-100 protein(s) on brain microtubule protein assembly
TL;DR: Data suggest that S-100 interferes with both the nucleation and the elongation of microtubules, and is suggested to affect the microtubule assembly by interacting with and sequestering tubulin.
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Role of the C-terminal extension in the interaction of S100A1 with GFAP, tubulin, the S100A1- and S100B-inhibitory peptide, TRTK-12, and a peptide derived from p53, and the S100A1 inhibitory effect on GFAP polymerization.
Marisa Garbuglia,Marco Verzini,Richard R. Rustandi,Dirk Osterloh,David J. Weber,Volker Gerke,Rosario Donato +6 more
TL;DR: Observations show that the C-terminal extension of S100A1 is an essential part of the S 100A1 site implicated in the recognition of GFAP, tubulin, p53, and the alpha-subunit of CapZ.
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Immunohistochemical localization of annexin V (CaBP33) in rat organs
TL;DR: The present data complement the biochemical work thus far done on annexin V and suggest that the protein is neither restricted to secretory cells nor exclusively related to exocytotic events insecretory cells.
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Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia.
Sara Chiappalupi,Guglielmo Sorci,Aleksandra Vukasinovic,Laura Salvadori,Roberta Sagheddu,Dario Coletti,Dario Coletti,Giorgia Renga,Luigina Romani,Rosario Donato,Francesca Riuzzi +10 more
TL;DR: It is demonstrated that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour‐derived cachexia‐inducing factors, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome.