S
Sara Beccafico
Researcher at University of Perugia
Publications - 14
Citations - 1027
Sara Beccafico is an academic researcher from University of Perugia. The author has contributed to research in topics: Skeletal muscle & Myocyte. The author has an hindex of 10, co-authored 14 publications receiving 935 citations. Previous affiliations of Sara Beccafico include University of Chieti-Pescara.
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Journal ArticleDOI
Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.
Gabriella Dobrowolny,Michela Aucello,Emanuele Rizzuto,Sara Beccafico,Cristina Mammucari,Simona Bonconpagni,Silvia Belia,Francesca Wannenes,Carmine Nicoletti,Zaccaria Del Prete,Nadia Rosenthal,Mario Molinaro,Feliciano Protasi,Giorgio Fanò,Marco Sandri,Antonio Musarò,Antonio Musarò +16 more
TL;DR: It is demonstrated that skeletal muscle is a primary target of SOD1(G93A) -mediated toxicity and the molecular mechanism whereby oxidative stress triggers muscle atrophy is disclosed.
Journal ArticleDOI
Age-dependent imbalance of the antioxidative system in human satellite cells.
Stefania Fulle,Silvia Di Donna,Cristina Puglielli,Tiziana Pietrangelo,Sara Beccafico,Rosa Grazia Bellomo,Feliciano Protasi,Giorgio Fanò +7 more
TL;DR: The present study shows that the antioxidant activity of Catalase and Gluthatione transferase in satellite cells derived from the elderly is drastically reduced compared to that in cells isolated from young individuals, and cell membrane fluidity is considerably different between the two age groups.
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Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation
Tiziana Pietrangelo,Cristina Puglielli,Rosa Mancinelli,Sara Beccafico,Giorgio Fanò,Stefania Fulle +5 more
TL;DR: The data show that the failure to differentiate does not depend on reduced myogenic cell number, but difficulty to complete the differentiation program, and the effects of aging on myoblasts and myotubes obtained from human skeletal muscle are characterized.
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Age-dependent effects on functional aspects in human satellite cells
Sara Beccafico,Cristina Puglielli,Tiziana Pietrangelo,Rosa Grazia Bellomo,Giorgio Fanò,Stefania Fulle +5 more
TL;DR: The results suggest that during donor's life the satellite cells undergo an aging process similar to the one observed in skeletal muscle tissue, even if they are in a quiescence status for most of the time.
Journal ArticleDOI
Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growth in vivo in embryonal rhabdomyosarcoma cells
Sara Beccafico,Giulio Morozzi,Maria Cristina Marchetti,Carlo Riccardi,Angelo Sidoni,Rosario Donato,Guglielmo Sorci +6 more
TL;DR: These results are the first evidence of efficacy of ART derivatives in restraining ERMS growth in vivo, and suggest ARS as a potential candidate for therapeutic treatment of ERMS.