R
Rosario Donato
Researcher at University of Perugia
Publications - 166
Citations - 14643
Rosario Donato is an academic researcher from University of Perugia. The author has contributed to research in topics: RAGE (receptor) & Myocyte. The author has an hindex of 51, co-authored 166 publications receiving 12919 citations.
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Journal ArticleDOI
Effects of calcium-binding proteins (S-100a(o), S-100a, S-100b) on desmin assembly in vitro.
TL;DR: The present data suggest that S‐100ao might play a role in the regulation of the state of assembly of desmin intermediate filaments.
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Microglia-glioma cross-talk: a two way approach to new strategies against glioma.
Cataldo Arcuri,Bernard Fioretti,Roberta Bianchi,Carmen Mecca,Claudia Tubaro,Tommaso Beccari,Fabio Franciolini,Ileana Giambanco,Rosario Donato +8 more
TL;DR: The microglia-glioma interactions are reviewed to highlight the close relationship between the two cell types and the factors that can influence their properties (chemokines, cytokines, S100B protein).
Journal ArticleDOI
S-100 (α and β) binding peptide (TRTK-12) blocks S-100/GFAP interaction: identification of a putative S-100 target epitope within the head domain of GFAP
Roberta Bianchi,Marisa Garbuglia,Marco Verzini,Ileana Giambanco,Vasily V. Ivanenkov,Ruth V.W. Dimlich,Gordon A. Jamieson,Rosario Donato +7 more
TL;DR: Results suggest TRTK-12 functions as a pleiotropic inhibitor of S-100 function, providing additional evidence supportive of a role for S- 100 as a multi-faceted regulator of cytoskeletal integrity.
Journal ArticleDOI
Mechanism of S100 protein-dependent inhibition of glial fibrillary acidic protein (GFAP) polymerization
TL;DR: The data suggest that S100 protein might serve the function of avoiding excess GFAP polymerization and might participate in remodeling of glial filaments following elevation of the intracellular free Ca2+ concentration.
Journal ArticleDOI
Hypoxia Promotes Danger-mediated Inflammation via Receptor for Advanced Glycation End Products in Cystic Fibrosis
Rossana G. Iannitti,Andrea Casagrande,Antonella De Luca,Cristina Cunha,Guglielmo Sorci,Francesca Riuzzi,Monica Borghi,Claudia Galosi,Cristina Massi-Benedetti,Tim D. Oury,Lisa Cariani,Maria Chiara Russo,Luigi Porcaro,Carla Colombo,Fabio Majo,Vincenzina Lucidi,Ersilia Fiscarelli,Gabriella Ricciotti,Cornelia Lass-Flörl,Luigi Ratclif,Antonella Esposito,Fernando Maria de Benedictis,Rosario Donato,Agostinho Carvalho,Luigina Romani +24 more
TL;DR: A causal link between hyperactivation of RAGE and inflammation in CF has been observed, such that targeting pathogenic inflammation alleviated inflammation inCF and measurement of sRAGE levels could be a useful biomarker for RAGE-dependent inflammation in patients with CF.