H
Hye Young Kim
Researcher at Harvard University
Publications - 28
Citations - 4515
Hye Young Kim is an academic researcher from Harvard University. The author has contributed to research in topics: Natural killer T cell & Inflammation. The author has an hindex of 24, co-authored 28 publications receiving 4149 citations. Previous affiliations of Hye Young Kim include Boston Children's Hospital & New Generation University College.
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Journal ArticleDOI
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
Ya-Jen Chang,Hye Young Kim,Lee A. Albacker,Nicole Baumgarth,Andrew Neil James Mckenzie,Dirk E. Smith,Rosemarie H. DeKruyff,Dale T. Umetsu +7 more
TL;DR: It is shown in a mouse model that influenza infection acutely induced airway hyper-reactivity (AHR), a cardinal feature of asthma, independently of T helper type 2 (TH2) cells and adaptive immunity.
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Extrathymically generated regulatory T cells control mucosal T H 2 inflammation
Steven Z. Josefowicz,Rachel E. Niec,Hye Young Kim,Piper M. Treuting,Takatoshi Chinen,Takatoshi Chinen,Ye Zheng,Dale T. Umetsu,Alexander Y. Rudensky +8 more
TL;DR: Whereas Treg cells generated in the thymus appear sufficient for control of systemic and tissue-specific autoimmunity, extrathymic differentiation of Treg Cells affects commensal microbiota composition and serves a distinct, essential function in restraint of allergic-type inflammation at mucosal interfaces.
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The many paths to asthma: phenotype shaped by innate and adaptive immunity
TL;DR: Animal models of asthma have helped to clarify some of the underlying mechanisms of asthma, demonstrating the importance of T helper type 2 (TH2)-driven allergic responses, as well as of the non-allergic and intrinsic pathways, and contributing to understanding of the heterogeneity of asthma.
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Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
Hye Young Kim,Hyun Jun Lee,Ya-Jen Chang,Muriel Pichavant,Stephanie A. Shore,Katherine A. Fitzgerald,Yoichiro Iwakura,Elliot Israel,Kenneth Bolger,John Faul,Rosemarie H. DeKruyff,Dale T. Umetsu +11 more
TL;DR: It is suggested that obesity-associated asthma is facilitated by inflammation mediated by NLRP3, IL-1β and ILC3 cells, which is found in the bronchoalveolar lavage fluid of individuals with asthma.
Journal ArticleDOI
Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
Muriel Pichavant,Sho Goya,Everett Meyer,Everett Meyer,Richard A. Johnston,Hye Young Kim,Ponpan Matangkasombut,Ming-Qiang Zhu,Yoichiro Iwakura,Paul B. Savage,Rosemarie H. DeKruyff,Stephanie A. Shore,Dale T. Umetsu +12 more
TL;DR: The results strongly suggest that NKT cells mediate a unifying pathogenic mechanism for several distinct forms of asthma, and represent a unique target for effective asthma therapy.