L
Lee A. Albacker
Researcher at Foundation Medicine
Publications - 99
Citations - 5872
Lee A. Albacker is an academic researcher from Foundation Medicine. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 24, co-authored 75 publications receiving 4197 citations. Previous affiliations of Lee A. Albacker include Harvard University & Brigham Young University.
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Journal ArticleDOI
Tissue expression of PD-L1 mediates peripheral T cell tolerance
Mary E. Keir,Spencer Liang,Indira Guleria,Yvette Latchman,A. Qipo,Lee A. Albacker,Maria Koulmanda,Gordon J. Freeman,Mohamed H. Sayegh,Arlene H. Sharpe +9 more
TL;DR: Evidence is provided that PD-L 1 expression on parenchymal cells rather than hematopoietic cells protects against autoimmune diabetes and point to a novel role for PD-1–PD-L1 interactions in mediating tissue tolerance.
Journal ArticleDOI
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
Ferdinandos Skoulidis,Michael E. Goldberg,Danielle Greenawalt,Matthew D. Hellmann,Mark M. Awad,Justin F. Gainor,Alexa B. Schrock,Ryan J. Hartmaier,Sally E. Trabucco,Siraj M. Ali,Julia A. Elvin,Gaurav Singal,Jeffrey S. Ross,David Fabrizio,Péter Szabó,Han Chang,Ariella Sasson,Sujaya Srinivasan,Stefan Kirov,Joseph D. Szustakowski,Patrik Vitazka,Robin Edwards,Jose A. Bufill,Neelesh Sharma,Sai-Hong Ignatius Ou,Nir Peled,Nir Peled,David R. Spigel,Hira Rizvi,Elizabeth Jimenez Aguilar,Brett W. Carter,Jeremy J. Erasmus,Darragh Halpenny,Andrew J. Plodkowski,Niamh Long,Mizuki Nishino,Warren Denning,Ana Galan-Cobo,Haifa Hamdi,Taghreed Hirz,Pan Tong,Jing Wang,Jaime Rodriguez-Canales,Pamela Villalobos,Edwin Roger Parra,Neda Kalhor,Lynette M. Sholl,Jennifer L. Sauter,Achim A. Jungbluth,Mari Mino-Kenudson,Roxana Azimi,Yasir Elamin,Jianjun Zhang,Giulia Costanza Leonardi,Fei Jiang,Fei Jiang,Kwok-Kin Wong,J. Jack Lee,Vassiliki A. Papadimitrakopoulou,Ignacio I. Wistuba,Vincent A. Miller,Garrett M. Frampton,Jedd D. Wolchok,Alice T. Shaw,Pasi A. Jänne,Philip J. Stephens,Charles M. Rudin,William J. Geese,Lee A. Albacker,John V. Heymach +69 more
TL;DR: Genomic profiling may enhance the predictive utility of PD-L1 expression and tumor mutation burden and facilitate establishment of personalized combination immunotherapy approaches for genomically defined LUAC subsets.
Journal ArticleDOI
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
Ya-Jen Chang,Hye Young Kim,Lee A. Albacker,Nicole Baumgarth,Andrew Neil James Mckenzie,Dirk E. Smith,Rosemarie H. DeKruyff,Dale T. Umetsu +7 more
TL;DR: It is shown in a mouse model that influenza infection acutely induced airway hyper-reactivity (AHR), a cardinal feature of asthma, independently of T helper type 2 (TH2) cells and adaptive immunity.
Journal ArticleDOI
Mechanisms and therapeutic implications of hypermutation in gliomas.
Mehdi Touat,Mehdi Touat,Mehdi Touat,Yvonne Y. Li,Yvonne Y. Li,Adam Boynton,Adam Boynton,Liam F. Spurr,Liam F. Spurr,J. Bryan Iorgulescu,J. Bryan Iorgulescu,Craig L. Bohrson,Isidro Cortes-Ciriano,Cristina Birzu,Jack Geduldig,Kristine Pelton,Mary Jane Lim-Fat,Mary Jane Lim-Fat,Sangita Pal,Sangita Pal,Ruben Ferrer-Luna,Ruben Ferrer-Luna,Ruben Ferrer-Luna,Shakti H. Ramkissoon,Shakti H. Ramkissoon,Frank Dubois,Frank Dubois,Charlotte Bellamy,Naomi Currimjee,Juliana Bonardi,Kenin Qian,Patricia Ho,Seth Malinowski,Leon Taquet,Robert E. Jones,Aniket Shetty,Kin-Hoe Chow,Radwa Sharaf,Dean Pavlick,Lee A. Albacker,Nadia Younan,Capucine Baldini,Maite Verreault,Marine Giry,Erell Guillerm,Samy Ammari,Samy Ammari,Frédéric Beuvon,Karima Mokhtari,Agusti Alentorn,Caroline Dehais,Caroline Houillier,Florence Laigle-Donadey,Dimitri Psimaras,Eudocia Q. Lee,Eudocia Q. Lee,Lakshmi Nayak,Lakshmi Nayak,J Ricardo McFaline-Figueroa,J Ricardo McFaline-Figueroa,Alexandre Carpentier,Philippe Cornu,Laurent Capelle,Bertrand Mathon,Jill S. Barnholtz-Sloan,Arnab Chakravarti,Wenya Linda Bi,E. Antonio Chiocca,Katie Pricola Fehnel,Sanda Alexandrescu,Susan N. Chi,Susan N. Chi,Daphne A. Haas-Kogan,Tracy T. Batchelor,Tracy T. Batchelor,Garrett M. Frampton,Brian M. Alexander,Brian M. Alexander,Raymond Y. Huang,Azra H. Ligon,Florence Coulet,Jean-Yves Delattre,Jean-Yves Delattre,Khê Hoang-Xuan,David Meredith,David Meredith,Sandro Santagata,Alex Duval,Marc Sanson,Marc Sanson,Andrew D. Cherniack,Andrew D. Cherniack,Patrick Y. Wen,Patrick Y. Wen,David A. Reardon,Aurélien Marabelle,Peter J. Park,Ahmed Idbaih,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Franck Bielle,Keith L. Ligon +105 more
TL;DR: Results show that chemotherapy can drive the acquisition of hypermutated populations without promoting a response to PD-1 blockade and supports the diagnostic use of mutational burden and signatures in cancer.
Journal ArticleDOI
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers.
Mark Yarchoan,Lee A. Albacker,Alexander Hopkins,Meagan Montesion,Karthikeyan Murugesan,Teena Vithayathil,Neeha Zaidi,Nilofer S. Azad,Daniel A. Laheru,Garrett M. Frampton,Elizabeth M. Jaffee +10 more
TL;DR: The results indicate that PD-L1 expression and TMB may each inform the use of ICIs, point to different mechanisms by which PD- L1 expression regulates ICI responsiveness, and identify new opportunities for therapeutic development.