E
Edward A. Greenfield
Researcher at Harvard University
Publications - 116
Citations - 11404
Edward A. Greenfield is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 35, co-authored 102 publications receiving 10475 citations. Previous affiliations of Edward A. Greenfield include Millennium Pharmaceuticals & Takeda Pharmaceutical Company.
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Journal ArticleDOI
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Yvette Latchman,Clive Wood,Tatyana Chernova,Divya Chaudhary,Madhuri Borde,Irene Chernova,Yoshiko Iwai,Andrew J. Long,Julia A. Brown,Raquel A. Nunes,Edward A. Greenfield,Karen Bourque,Vassiliki A. Boussiotis,Laura L. Carter,Beatriz M. Carreno,Nelly Malenkovich,Hiroyuki Nishimura,Taku Okazaki,Tasuku Honjo,Arlene H. Sharpe,Gordon J. Freeman +20 more
TL;DR: These studies show overlapping functions of PD-L1 andPD-L2 and indicate a key role for the PD- L–PD-1 pathway in regulating T cell responses.
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Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
Laurent Monney,Catherine A. Sabatos,Jason L. Gaglia,Akemi Ryu,Hanspeter Waldner,Tatyana Chernova,Stephen Manning,Edward A. Greenfield,Edward A. Greenfield,Anthony J. Coyle,Raymond A. Sobel,Gordon J. Freeman,Vijay K. Kuchroo +12 more
TL;DR: In vivo administration of antibody to Tim-3 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and increases the number and activation level of macrophages.
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Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production
Julia A. Brown,David M. Dorfman,Feng-Rong Ma,Elizabeth L. Sullivan,Oliver Munoz,Clive Wood,Edward A. Greenfield,Gordon J. Freeman +7 more
TL;DR: It is shown that blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-γ and IL-10, which is consistent with the hypothesis that iDC have a balance of stimulatory vs inhibitory molecules that favors inhibition.
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Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
Omid Akbari,Gordon J. Freeman,Everett Meyer,Edward A. Greenfield,Tammy T. Chang,Arlene H. Sharpe,Gerald J. Berry,Rosemarie H. DeKruyff,Dale T. Umetsu +8 more
TL;DR: It is demonstrated that TR cells and the ICOS–ICOS-ligand signaling pathway are critically involved in respiratory tolerance and in downregulating pulmonary inflammation in asthma.
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Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells
Alexander J. McAdam,Alexander J. McAdam,Tammy T. Chang,Anna E. Lumelsky,Edward A. Greenfield,Vassiliki A. Boussiotis,Jonathan S. Duke-Cohan,Tatyana Chernova,Nelly Malenkovich,Claudia Jabs,Vijay K. Kuchroo,Vincent Ling,Mary Collins,Arlene H. Sharpe,Gordon J. Freeman +14 more
TL;DR: Investigating the role of ICOS in activation of CD4+ T cells and its role in Th responses demonstrated that ICOS stimulation is important in T cell activation and thatICOS may have a particularly important role in development of Th2 cells.