R
Ruby Jiang
Researcher at University of British Columbia
Publications - 12
Citations - 705
Ruby Jiang is an academic researcher from University of British Columbia. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 10, co-authored 12 publications receiving 653 citations. Previous affiliations of Ruby Jiang include Family Research Institute.
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Journal ArticleDOI
Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia
Kathleen Kaiser-Rogers,Deborah E. McFadden,Chad A. Livasy,Jerome Dansereau,Ruby Jiang,Judith Knops,Louis Lefebvre,Kathleen W. Rao,Wendy P. Robinson +8 more
TL;DR: Androgenetic mosaicism for the first time provides an aetiology for PMD, and may be a novel mechanism for Beckwith-Wiedemann syndrome and unexplained intrauterine growth restriction.
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Mecp2 promoter methylation and x chromosome inactivation in autism
Raman P. Nagarajan,Katherine A. Patzel,Michelle R. Martin,Dag H. Yasui,Susan E. Swanberg,Irva Hertz-Picciotto,Robin L Hansen,Judith A Van de Water,Isaac N. Pessah,Ruby Jiang,Wendy P. Robinson,Janine M. LaSalle +11 more
TL;DR: The results suggest that the aberrant MECP2 methylation in autism brain DNA samples is due to locus‐specific rather than global X chromosome methylation changes.
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Evaluating DNA methylation and gene expression variability in the human term placenta
Luana Avila,Luana Avila,Ryan K. C. Yuen,Ryan K. C. Yuen,D. Diego-Alvarez,D. Diego-Alvarez,D. Diego-Alvarez,Maria S. Peñaherrera,Maria S. Peñaherrera,Ruby Jiang,Ruby Jiang,Wendy P. Robinson,Wendy P. Robinson +12 more
TL;DR: Within-placenta correlations in expression and methylation from unrelated genes raise the possibility that methylation and expression variation may potentially reflect cell composition differences between samples rather than true differences occurring at the cellular level.
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Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies.
Ryan K. C. Yuen,Ryan K. C. Yuen,Ruby Jiang,Ruby Jiang,Maria S. Peñaherrera,Maria S. Peñaherrera,Deborah E. McFadden,Wendy P. Robinson,Wendy P. Robinson +8 more
TL;DR: Comparison of DNA methylation for known imprinted genes between placentas of different gestations and other somatic tissues provides a detailed analysis of specific CpG sites associated with tissue-specific imprinting and gestational age-specific methylation.
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Skewed X-Chromosome Inactivation Is Associated with Trisomy in Women Ascertained on the Basis of Recurrent Spontaneous Abortion or Chromosomally Abnormal Pregnancies
C. L. Beever,Mary D. Stephenson,Maria S. Peñaherrera,Ruby Jiang,Dagmar K. Kalousek,Michael R. Hayden,L. Leigh Field,Carolyn J. Brown,Wendy P. Robinson +8 more
TL;DR: It is hypothesized that the association between skewed XCI and trisomic pregnancies is produced by a common mechanism that underlies both and that involves a reduction of the size of the follicular pool.