K
Kathleen W. Rao
Researcher at University of North Carolina at Chapel Hill
Publications - 75
Citations - 4910
Kathleen W. Rao is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Myeloid leukemia & Chromosome 21. The author has an hindex of 30, co-authored 75 publications receiving 4668 citations. Previous affiliations of Kathleen W. Rao include Memorial Hospital of South Bend & Mayo Clinic.
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Journal ArticleDOI
Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)
John C. Byrd,Krzysztof Mrózek,Richard K. Dodge,Andrew J. Carroll,Colin G. Edwards,Diane C. Arthur,Mark J. Pettenati,Shivanand R. Patil,Kathleen W. Rao,Michael S. Watson,Prasad Koduru,Joseph O. Moore,Richard Stone,Robert J. Mayer,Eric J. Feldman,Frederick R. Davey,Charles A. Schiffer,Richard A. Larson,Clara D. Bloomfield +18 more
TL;DR: In this paper, the prognostic impact of cytogenetic abnormalities on complete remission (CR) rate, 5-year cumulative incidence of relapse (CIR), and 5-to-5-year overall survival (OS) of acute myeloid leukemia (AML) patients was investigated.
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The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies
Jan O. Korbel,Tal Tirosh-Wagner,Alexander E. Urban,Xiao Ning Chen,Maya Kasowski,Li Dai,Fabian Grubert,Chandra Erdman,Michael C. Gao,Ken Lange,Eric M. Sobel,Gillian M. Barlow,Arthur S. Aylsworth,Nancy J. Carpenter,Robin D. Clark,Monika Y. Cohen,Eric Doran,Tzipora C Falik-Zaccai,Susan O. Lewin,Ira T. Lott,Barbara McGillivray,John B. Moeschler,Mark J. Pettenati,Siegfried M. Pueschel,Kathleen W. Rao,Lisa G. Shaffer,Mordechai Shohat,Alexander J. Van Riper,Dorothy Warburton,Dorothy Warburton,Sherman M. Weissman,Mark Gerstein,Michael Snyder,Julie R. Korenberg,Julie R. Korenberg,Julie R. Korenberg +35 more
TL;DR: A high-resolution genetic map of DS phenotypes based on an analysis of 30 subjects carrying rare segmental trisomies of various regions of HSA21 is presented, demonstrating the value of combining advanced genomics with cohorts of rare patients for studying DS, a prototype for the role of copy-number variation in complex disease.
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Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism.
Christa Lese Martin,Jacqueline A. Duvall,Yesim Ilkin,Jason S. Simon,M. Gladys Arreaza,Kristin Wilkes,Ana Isabel Alvarez-Retuerto,Amy Whichello,Cynthia M. Powell,Kathleen W. Rao,Edwin H. Cook,Daniel H. Geschwind +11 more
TL;DR: A de novo translocation between the short arms of chromosomes 15 and 16 in a female with autism, epilepsy, and global developmental delay is reported, suggesting that A2BP1 may affect susceptibility or cause autism in a subset of patients.
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Tyrosine Kinase Inhibitor Therapy Induces Remission in a Patient With Refractory EBF1-PDGFRB–Positive Acute Lymphoblastic Leukemia
Brent W. Weston,Melissa A. Hayden,Kathryn G. Roberts,Susan Bowyer,Johann Hsu,George Fedoriw,Kathleen W. Rao,Charles G. Mullighan +7 more
TL;DR: A child with EBF1PDGFRB–positive ALL is presented whose disease was refractory to conventional induction chemotherapy but who responded to the addition of imatinib to remission induction therapy, highlighting the potential for TKI therapy to improve the currently poor outcome of patients with BCR-ABL1–like ALL harboring kinase-activating alterations.
Journal ArticleDOI
Preliminary phenotypic map of chromosome 4p16 based on 4p deletions.
Laurel L. Estabrooks,Kathleen W. Rao,Deborah A. Driscoll,Barbara F. Crandall,John Dean,Elina Ikonen,Bruce R. Korf,Arthur S. Aylsworth +7 more
TL;DR: Initial observations and attempts at genotype/phenotype correlation lay the groundwork for identifying the genetic basis of these malformations, a common objective of gene mapping efforts and chromosome deletion studies.