R
Rudolf Volkmer
Researcher at Charité
Publications - 91
Citations - 4129
Rudolf Volkmer is an academic researcher from Charité. The author has contributed to research in topics: Epitope & PDZ domain. The author has an hindex of 28, co-authored 90 publications receiving 3572 citations. Previous affiliations of Rudolf Volkmer include Leibniz Institute for Neurobiology.
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Journal ArticleDOI
Histone recognition and large-scale structural analysis of the human bromodomain family.
Panagis Filippakopoulos,Sarah Picaud,Maria M. Mangos,T. Keates,Jean-Philippe Lambert,Dalia Barsyte-Lovejoy,I. Felletar,Rudolf Volkmer,Susanne Müller,Tony Pawson,Anne-Claude Gingras,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Stefan Knapp,Stefan Knapp,Stefan Knapp +15 more
TL;DR: Bromodomains are protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks, and a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4 is uncovered.
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Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Anna Ulbricht,Felix J. Eppler,Victor Tapia,Peter F.M. van der Ven,Nico Hampe,Nils Hersch,Padmanabhan Vakeel,Daniela Stadel,Albert Haas,Paul Saftig,Christian Behrends,Dieter O. Fürst,Rudolf Volkmer,Bernd Hoffmann,Waldemar Kolanus,Jörg Höhfeld +15 more
TL;DR: By integrating tension sensing, autophagosome formation, and transcription regulation during mechanotransduction, the CASA machinery ensures tissue homeostasis and regulates fundamental cellular processes such as adhesion, migration, and proliferation.
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Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins
Raffi Tonikian,Xiaofeng Xin,Christopher P. Toret,David Gfeller,Christiane Landgraf,Simona Panni,Simona Panni,Serena Paoluzi,Luisa Castagnoli,Bridget Currell,Somasekar Seshagiri,Haiyuan Yu,Barbara Winsor,Marc Vidal,Mark Gerstein,Gary D. Bader,Rudolf Volkmer,Gianni Cesareni,David G. Drubin,Philip M. Kim,Sachdev S. Sidhu,Charles Boone +21 more
TL;DR: A genome-scale specificity and interaction map for yeast SH3 domain-containing proteins reveal how family members show selective binding to target proteins and predicts the dynamic localization of new candidate endocytosis proteins.
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Comparison of cellular uptake using 22 CPPs in 4 different cell lines.
TL;DR: This work demonstrates that the 22 CPPs can be classified into 3 groups based on their internalization properties, even after trypsinization, and shows that additional agents, which should increase cellular uptake or dissolve endosomal/lysosomal entrapped C PPs, only have low effects.
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SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses
Seong Joo Koo,Stefan Markovic,Dmytro Puchkov,Carsten C. Mahrenholz,Figen Beceren-Braun,Tanja Maritzen,Jens Dernedde,Rudolf Volkmer,Hartmut Oschkinat,Volker Haucke +9 more
TL;DR: In this article, the authors show that synaptobrevin 2 sorting involves determinants within its SNARE motif that are recognized by the ANTH domains of the endocytic adaptors AP180 and clathrin assembly lymphoid myeloid leukemia (CALM).