R
Rui-Chao Chai
Researcher at Capital Medical University
Publications - 42
Citations - 1725
Rui-Chao Chai is an academic researcher from Capital Medical University. The author has contributed to research in topics: Glioma & Astrocyte. The author has an hindex of 17, co-authored 41 publications receiving 715 citations. Previous affiliations of Rui-Chao Chai include Peking University & National Health and Family Planning Commission.
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Journal ArticleDOI
Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients.
Zheng Zhao,Kenan Zhang,Qiang-Wei Wang,Guanzhang Li,Fan Zeng,Ying Zhang,Fan Wu,Rui-Chao Chai,Zheng Wang,Chuanbao Zhang,Wei Zhang,Zhaoshi Bao,Tao Jiang +12 more
TL;DR: Wang et al. as mentioned in this paper developed the Chinese Glioma Genome Atlas (CGGA), a userfriendly data portal for the storage and interactive exploration of cross-omics data, including nearly 2000 primary and recurrent glioma samples from Chinese cohort.
Posted ContentDOI
Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients
Zheng Zhao,Kenan Zhang,Qiangwei Wang,Guanzhang Li,Fan Zeng,Ying Zhang,Fan Wu,Rui-Chao Chai,Zheng Wang,Chuanbao Zhang,Wei Zhang,Zhaoshi Bao,Tao Jiang +12 more
TL;DR: The Chinese Glioma Genome Atlas (CGGA) is developed, a user-friendly data portal for storage and interactive exploration of multi-dimensional functional genomic data that includes nearly 2,000 primary and recurrent glioma samples from Chinese cohorts and develops an analysis tool to allow users to browse mutational, mRNA/microRNA expression, and DNA methylation profiles and perform survival and correlation analyses of specificglioma subtypes.
Journal ArticleDOI
m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas.
Rui-Chao Chai,Fan Wu,Qixue Wang,Shu Zhang,Kenan Zhang,Yu-Qing Liu,Zheng Zhao,Tao Jiang,Yong-Zhi Wang,Chunsheng Kang,Chunsheng Kang +10 more
TL;DR: It is demonstrated that most of the thirteen main m6A RNA methylation regulators are differentially expressed among gliomas stratified by different clinicopathological features in 904gliomas, and derived a risk signature that is not only an independent prognostic marker but can also predict the clinicopathic features of glioma malignancy.
Journal ArticleDOI
Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression
Kai Gao,Chen Ran Wang,Feng Jiang,Ann Yuen Kwan Wong,Na Su,Jiao Hua Jiang,Rui-Chao Chai,Greg Vatcher,Junlin Teng,Jianguo Chen,Yu-Wu Jiang,Albert Cheung Hoi Yu,Albert Cheung Hoi Yu +12 more
TL;DR: It is demonstrated that traumatic scratch injury to astrocytes triggered a calcium influx from the extracellular compartment and activated the JNK/c‐Jun/AP‐1 pathway to switch on GFAP expression, identifying a previously unreported signaling cascade that is important in astrogliosis and the physiological response following brain injury.
Journal ArticleDOI
YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma.
Rui-Chao Chai,Yu-Zhou Chang,Xin Chang,Bo Pang,Song Yuan An,Kenan Zhang,Yuanhao Chang,Tao Jiang,Yongzhi Wang +8 more
TL;DR: In this paper, the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m6A) reader, YTH N6-methyladenosines RNA binding protein 2 (YTHDF2), in regulating the malignant progression of gliomas was investigated.