Yongzhi Wang

TL;DR: The recommendations will provide a framework and assurance for the strategy of diagnostic and therapeutic measures to reduce complications from unnecessary treatment and cost and should serve as an application for all professionals involved in the management of patients with adult diffuse glioma and also as a source of knowledge for insurance companies and other institutionsinvolved in the cost regulation of cancer care in China.

TL;DR: Recent advancements in the molecular mechanism, multimodal treatment and clinical management, and the updated view on the biomarkers in patients with HGG are reviewed, both in primary and recurrent setting, with an emphasis on targeted therapies tailored to the patient.

TL;DR: The results reveal that 3 main subtypes stably exist in Chinese patients with glioma, and the classification scheme may reflect the clinical and genetic alterations more clearly.

TL;DR: Age, preoperative Karnofsky performance scale (KPS), pathological type, radiotherapy, O6-methylguanine-DNA methyltransferase (MGMT) expression and Ki-67 expression, were significant associated with OS in multivariate analyses; and preoperative KPS and radiotherapy were significantly associated with progression-free survival (PFS).

TL;DR: This is the first study to identify the MMP-9 specific microRNA signature which may provide potential targets for anti-invasion therapy in GBM and found that miR-491-5p suppressed glioma cell invasion via targeting M MP-9 directly.