Rui-Chao Chai

TL;DR: Wang et al. as mentioned in this paper developed the Chinese Glioma Genome Atlas (CGGA), a userfriendly data portal for the storage and interactive exploration of cross-omics data, including nearly 2000 primary and recurrent glioma samples from Chinese cohort.

TL;DR: The Chinese Glioma Genome Atlas (CGGA) is developed, a user-friendly data portal for storage and interactive exploration of multi-dimensional functional genomic data that includes nearly 2,000 primary and recurrent glioma samples from Chinese cohorts and develops an analysis tool to allow users to browse mutational, mRNA/microRNA expression, and DNA methylation profiles and perform survival and correlation analyses of specificglioma subtypes.

TL;DR: It is demonstrated that most of the thirteen main m6A RNA methylation regulators are differentially expressed among gliomas stratified by different clinicopathological features in 904gliomas, and derived a risk signature that is not only an independent prognostic marker but can also predict the clinicopathic features of glioma malignancy.

TL;DR: It is demonstrated that traumatic scratch injury to astrocytes triggered a calcium influx from the extracellular compartment and activated the JNK/c‐Jun/AP‐1 pathway to switch on GFAP expression, identifying a previously unreported signaling cascade that is important in astrogliosis and the physiological response following brain injury.

TL;DR: In this paper, the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m6A) reader, YTH N6-methyladenosines RNA binding protein 2 (YTHDF2), in regulating the malignant progression of gliomas was investigated.