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Ruimin Xu
Researcher at Tongji University
Publications - 3
Citations - 143
Ruimin Xu is an academic researcher from Tongji University. The author has contributed to research in topics: Chromatin & Somatic cell. The author has an hindex of 3, co-authored 3 publications receiving 57 citations.
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Journal ArticleDOI
Insights into epigenetic patterns in mammalian early embryos
TL;DR: The aim of this review is to highlight the most recent progress in understanding the mechanisms of epigenetic remodeling during early embryogenesis in mammals, including DNA methylation, histone modifications, chromatin accessibility and 3D chromatin organization.
Journal ArticleDOI
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos
Mo Chen,Qianshu Zhu,Chong Li,Xiaochen Kou,Yanhong Zhao,Yanhe Li,Ruimin Xu,Lei Yang,Lingyue Yang,Liang Gu,Hong Wang,Xiaoyu Liu,Cizhong Jiang,Shaorong Gao +13 more
TL;DR: It is found that donor cell chromatin transforms to the metaphase state rapidly after SCNT along with the dissolution of typical 3D chromatin structure, and insight is provided into chromatin architecture reorganisation during SCNT embryo development.
Journal ArticleDOI
Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b
Wenteng He,Xiaobai Zhang,Yalin Zhang,Weisheng Zheng,Zeyu Xiong,Xinjie Hu,Mingzhu Wang,Linfeng Zhang,Kun Zhao,Zhibin Qiao,Weiyi Lai,Cong Lv,Xiaochen Kou,Yanhong Zhao,Jiqing Yin,Wenqiang Liu,Yonghua Jiang,Mo Chen,Ruimin Xu,Rongrong Le,Chong Li,Hong Wang,Xiaoping Wan,Hailin Wang,Zhiming Han,Cizhong Jiang,Shaorong Gao,Jiayu Chen +27 more
TL;DR: It is found that the genome-wide DNA methylation level in AG-haESCs is extremely low, and downregulation of both de novo methyltransferase Dnmt3b and other methylation-related genes was determined to be responsible for DNA hypomethylation.