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Shuiqing Yu
Researcher at Columbia University
Publications - 20
Citations - 1450
Shuiqing Yu is an academic researcher from Columbia University. The author has contributed to research in topics: Heart failure & Triglyceride. The author has an hindex of 15, co-authored 20 publications receiving 1272 citations. Previous affiliations of Shuiqing Yu include New York University.
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Journal ArticleDOI
Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure
Aalap Chokshi,Konstantinos Drosatos,Faisal H. Cheema,Ruiping Ji,Tuba Khawaja,Shuiqing Yu,Tomoko Kato,Raffay S. Khan,Hiroo Takayama,Ralph Knöll,Hendrik Milting,Hendrik Milting,Christine Chung,Ulrich P. Jorde,Yoshifumi Naka,Donna Mancini,Ira J. Goldberg,P. Christian Schulze +17 more
TL;DR: Mechanical unloading after left ventricular assist device implantation corrects systemic and local metabolic derangements in advanced heart failure, leading to reduced myocardial levels of toxic lipid intermediates and improved cardiac insulin signaling.
Journal ArticleDOI
ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet
Naoki Terasaka,Shuiqing Yu,Laurent Yvan-Charvet,Nan Wang,Nino Mzhavia,Read Langlois,Tamara A. Pagler,Rong Li,Carrie L. Welch,Ira J. Goldberg,Alan R. Tall +10 more
TL;DR: The data suggest that ABCG1 and HDL maintain EC function in HCD-fed mice by promoting efflux of cholesterol and 7-oxysterols and preserving active eNOS dimer levels.
Journal ArticleDOI
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
Ni Huiping Son,Shuiqing Yu,Joseph Tuinei,Kotaro Arai,Hiroko Hamai,Shunichi Homma,Gerald I. Shulman,E. Dale Abel,Ira J. Goldberg +8 more
TL;DR: In this paper, mice with dilated Cardiomyopathy due to cardiomyocyte PPARγ overexpression were crossed with PPARα-deficient mice, and the cross led to enhanced expression of several PPAR-regulated genes that mediate fatty acid uptake/oxidation and triacylglycerol (TAG) synthesis.
Journal ArticleDOI
Diabetes Induces Endothelial Dysfunction but Does Not Increase Neointimal Formation in High-Fat Diet Fed C57BL/6J Mice
TL;DR: It is suggested that additional diabetes associated parameters (such as hyperlipidemia and atherosclerotic vascular disease) may need to be present to increase neointimal formation in this model of diet induced obesity/diabetes.
Journal ArticleDOI
Endothelial cell CD36 optimizes tissue fatty acid uptake
Ni-Huiping Son,Debapriya Basu,Dmitri Samovski,Terri A. Pietka,Vivek S. Peche,Florian Willecke,Xiang Fang,Shuiqing Yu,Diego Scerbo,Hye Rim Chang,Fei Sun,Svetlana Bagdasarov,Konstantinos Drosatos,Steve T Yeh,Adam E. Mullick,Kooresh I. Shoghi,Namrata Gumaste,Kyeong Jin Kim,Lesley-Ann Huggins,Tenzin Lhakhang,Nada A. Abumrad,Ira J. Goldberg +21 more
TL;DR: It is shown that EC CD36 acts as a gatekeeper for parenchymal cell FA uptake, with important downstream effects on glucose utilization and insulin action.