R
Rumi Sawada
Researcher at Ochanomizu University
Publications - 33
Citations - 585
Rumi Sawada is an academic researcher from Ochanomizu University. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 12, co-authored 31 publications receiving 532 citations.
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Journal ArticleDOI
FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-β2
TL;DR: Results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-beta2 expression.
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FGF-2 increases osteogenic and chondrogenic differentiation potentials of human mesenchymal stem cells by inactivation of TGF-β signaling
TL;DR: The results suggested that the inactivation of IGF-I and TGF-β signaling promotes osteogenic and chondrogenic differentiation potential of hMSCs in the presence of FGF-2.
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Higher susceptibility of NOG mice to xenotransplanted tumors.
Kazuhiko Machida,Hiroshi Suemizu,Kenji Kawai,Tsuyoshi Ishikawa,Rumi Sawada,Yasuyuki Ohnishi,Toshie Tsuchiya +6 more
TL;DR: Comparing the susceptibility of NOG, SCID, and traditionally used nude mice to tumor formation from xenotransplanted HeLa S3 cells suggests that NOG mice may be the best choice as a suitable strain for testing tumorigenicity.
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Changes in expression of genes related to cell proliferation in human mesenchymal stem cells during in vitro culture in comparison with cancer cells
TL;DR: HMSCs derived from bone marrow seldom underwent spontaneous transformation during 1–2 months of in vitro culture for use in clinical applications, and growth might be controlled by the TGFβ family signaling.
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Calcium-incorporated titanium surfaces influence the osteogenic differentiation of human mesenchymal stem cells.
TL;DR: In this article, a titanium surface was chemically modified with calcium ions and assessed for its influence on osteogenic differentiation and molecular responses of human mesenchymal stem cells (hMSCs).