Rumiko Saito

TL;DR: The value of high-coverage sequencing for constructing population-specific variant panels, which covers 99.0% SNVs of minor allele frequency ≥0.1%, is demonstrated, and its value for identifying causal rare variants of complex human disease phenotypes in genetic association studies is demonstrated.

TL;DR: Counting on CAMP induction in innate stimuli, such as in infection and wounding, IL-36γ induction by cathelicidin would explain the mechanism of initiation of skin inflammation and occasional exacerbations of psoriasis and skin diseases by general infection.

TL;DR: The Japonica array provides better imputation performance for Japanese individuals than the existing commercially available SNP arrays with both the 1KJPN panel and the International 1000 genomes project panel.

TL;DR: A stable THP-1-derived IL-8 reporter cell line is established, which harbors SLO and SLR luciferase genes under the control ofIL-8 and glyceraldehyde 3-phosphate dehydrogenase promoters, respectively, and is a candidate replacement for animal tests of skin sensitization because of its accuracy, convenience, and high throughput performance.

TL;DR: A novel role of IL-4/IL-13–induced DUOX1 expression is revealed in making a positive feedback loop for IL- 4/il-13 signaling in keratinocytes.