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Runfeng Li
Researcher at Guangzhou Medical University
Publications - 28
Citations - 447
Runfeng Li is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 10, co-authored 19 publications receiving 295 citations.
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Journal ArticleDOI
Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway.
Qinhai Ma,Runfeng Li,Weiqi Pan,Wenbo Huang,Bin Liu,Yuqi Xie,Zhoulang Wang,Chufang Li,Haiming Jiang,Jicheng Huang,Yongxia Shi,Jun Dai,Kui Zheng,Xiaobo Li,Min Hui,Li Fu,Zifeng Yang,Zifeng Yang +17 more
TL;DR: Investigation of the antiviral and anti-inflammatory activities of KD-1 against the novel SARS-CoV-2 and H coV-229E indicated that KD- 1 protected against virus and can thus be used as a novel strategy for controlling coronavirus 2019.
Journal ArticleDOI
The tree shrew provides a useful alternative model for the study of influenza H1N1 virus
Zifeng Yang,Zifeng Yang,Jin Zhao,Yu-tong Zhu,Yutao Wang,Rong Liu,Suishan Zhao,Runfeng Li,Chunguang Yang,Ji-qiang Li,Nanshan Zhong +10 more
TL;DR: It is proposed that tree shrews could be a useful alternative mammalian model to study pathogenesis of influenza H1N1 virus.
Journal ArticleDOI
Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.
Jianghong Dong,Shengwei Chen,Runfeng Li,Wei Cui,Haiming Jiang,Yixia Ling,Zifeng Yang,Wenhui Hu +7 more
TL;DR: In this article, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidaze ring of this compound, which was identified as being active on an amantadine-sensitive virus through blocking of the viral M2 ion channel.
Journal ArticleDOI
Efficacy of delayed treatment of China-made Peramivir with repeated intravenous injections in a mouse influenza model: from clinical experience to basal experiment
Li Zhengtu,Runfeng Li,Jing Li,Hui Xie,Yanbing Hao,Qiuling Du,Tingting Chen,Yimin Li,Rongchang Chen,Zifeng Yang,Zifeng Yang,Nanshan Zhong,Nanshan Zhong +12 more
TL;DR: Delayed treatment with China-made Peramivir can reduce the severity of influenza disease, accelerate viral clearance and enhance the survival rate, and this drug shows good efficacy and is a promising candidate to control the influenza epidemic in China.
Journal ArticleDOI
Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret).
Yutao Wang,Yuewen Ding,Chunguang Yang,Runfeng Li,Qiuling Du,Yanbing Hao,Li Zhengtu,Haiming Jiang,Jin Zhao,Qiaoyan Chen,Zifeng Yang,Zifeng Yang,Zhanlong He +12 more
TL;DR: The results clarified the activity of ARB in both suppressing virus propagation and modulating the expression of inflammatory cytokines in vitro and in vivo, it can be as an effective drug to treat the influenza virus infection.